The comparison of neuroprotective effects of intrathecal dexmedetomidine and metilprednisolone in spinal cord injury
| Autor: | Abdulmenap Güzel, Ugur Firat, Kağan Kamaşak, Feyzi Çelik, Adnan Tüfek, Cüneyt Göçmez, Osman Evliyaoglu, Orhan Tokgöz |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Necrosis
medicine.medical_treatment Hemorrhage Spinal cord injury Intrathecal Methylprednisolone Neuroprotection Statistics Nonparametric medicine Animals Rats Wistar Dexmedetomidine Injections Spinal Spinal Cord Injuries Histocytochemistry business.industry Laminectomy General Medicine medicine.disease Rats Disease Models Animal Catheter Neuroprotective Agents Spinal Cord Anesthesia Female Surgery medicine.symptom business medicine.drug |
| Zdroj: | International Journal of Surgery. 11(5):414-418 |
| ISSN: | 1743-9191 |
| DOI: | 10.1016/j.ijsu.2013.03.008 |
| Popis: | BackgroundThe purpose of this study is the investigation of the effects of intrathecally injected dexmedetomidine and methylprednisolone and their dominancy over one another in rats with generated Spinal Cord Injury (SCI).Methods40, female, adult Wistar Albino rats weighing 220–260 g were included in the study. The rats were fixed with Intrathecal catheter (IT) and divided into four groups. All subjects were applied T7–10 laminectomy after catheter. Group S (n:10) was injected with IT 10 μL isotonic saline; Group C (n:10) with IT 10 μL isotonic saline after SCI; Group D (n:10) with IT one doze 10 μL of dexmedetomidine after SCI; Group M (n:10) IT one dose 10 μL of methylprednisolone. The subjects were sacrificed 72 h after this operation. The damaged area was removed biochemically and histopathologically examined.ResultsAntioxidant and inflammatory parameters searched for in all damages tissue were statistically different in all groups from group S. They were different in group M and group D than group C (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect