The contrasting phylodynamics of human influenza B viruses
| Autor: | Rebecca A. Halpin, William D. Rawlinson, Mathieu Fourment, Edward C. Holmes, Dhanasekaran Vijaykrishna, Vithiagaran Gunalan, Nadia Fedorova, Aeron C. Hurt, Bin Zhou, Natalie Spirason, Yvonne C. F. Su, David E. Wentworth, Lance C. Jennings, Anna-Maria Costa, Udayan Joseph, Ian G. Barr, Sheena G. Sullivan, Dominic E. Dwyer, Gavin J. D. Smith, Q. Sue Huang, Yi-Mo Deng, Denise Kühnert, Sebastian Maurer-Stroh, Veronika Boskova, Raphael T.C. Lee, Xudong Lin, Tanja Stadler, Timothy B. Stockwell |
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| Přispěvatelé: | School of Biological Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular Glycosylation Time Factors Hemagglutinin Glycoproteins Influenza Virus medicine.disease_cause influenza virus Madin Darby Canine Kidney Cells Science::Biological sciences::Human anatomy and physiology [DRNTU] Evolution of influenza Influenza A virus Biology (General) Antigens Viral Phylogeny Microbiology and Infectious Disease General Neuroscience General Medicine Genomics and Evolutionary Biology Viral evolution Medicine epidemiology Asparagine Reassortant Viruses Research Article Victoria QH301-705.5 Science Genome Viral Biology H5N1 genetic structure General Biochemistry Genetics and Molecular Biology Antigenic drift Virus Evolution Molecular Age Distribution Dogs Influenza Human evolution medicine Animals Humans viruses human Selection Genetic antigenic drift General Immunology and Microbiology Genetic Variation Virology Influenza B virus Viral phylodynamics New Zealand |
| Zdroj: | eLife, 4 eLife eLife, Vol 4 (2015) |
| ISSN: | 2050-084X |
| DOI: | 10.3929/ethz-b-000098273 |
| Popis: | A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology. eLife, 4 ISSN:2050-084X |
| Databáze: | OpenAIRE |
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