Retrograde autologous priming of the cardiopulmonary bypass circuit reduces blood transfusion after coronary artery surgery
| Autor: | Sivagnanam Karthikeyan, M. H. Cross, Peter Hobson, Stephen D. Hansbro, Subramaniam Balachandran, A. K. Mulpur |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Blood transfusion medicine.medical_treatment Priming (immunology) Hematocrit law.invention Blood Transfusion Autologous Randomized controlled trial law medicine Cardiopulmonary bypass Humans Blood Transfusion Prospective Studies Derivation Coronary Artery Bypass Prospective cohort study Cardiopulmonary Bypass medicine.diagnostic_test business.industry Equipment Design Intensive care unit Surgery Anesthesia Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of Thoracic Surgery. 73:1912-1918 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/s0003-4975(02)03513-0 |
| Popis: | Background . Hemodilution occurring with cardiopulmonary bypass imposes a risk for blood transfusion. Autologous priming of the cardiopulmonary bypass circuit at the initiation of bypass partially replaces the priming solution with autologous blood. We examined the efficacy of autologous priming of the circuit in reducing blood transfusion. Methods . One hundred and four patients were entered into a prospective, randomized, controlled study. Initiation of cardiopulmonary bypass was with or without autologous priming. Results . With autologous priming, a mean volume of 808.8 ± 159.3 mL of priming solution was replaced with autologous blood. This allowed a higher hematocrit value on admission to the intensive care unit and at discharge from hospital. In all, 49% of the control group required a blood transfusion compared with 17% from the autologous priming group ( p = 0.0007). The mean volume of blood transfused was 277.6 ± 363.8 mL in the control group compared with 70.1 ± 173.5 mL in the autologous priming group ( p = 0.0005). Conclusions. Retrograde autologous priming of the bypass circuit reduces homologous blood transfusion owing to the reduction in bypass circuit priming volume. |
| Databáze: | OpenAIRE |
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