Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner
| Autor: | Markus Affolter, Suzanne Eaton, Maria Leptin, Magdalena M. Baer, Wilhelm Palm |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Apolipoprotein B Lumen (anatomy) 03 medical and health sciences 0302 clinical medicine Animals Secretion Molecular Biology Triglycerides 030304 developmental biology 0303 health sciences biology Endoplasmic reticulum Cell Biology Apical membrane In vitro 3. Good health Trachea Biochemistry Models Animal biology.protein Microsome Drosophila Female lipids (amino acids peptides and proteins) Carrier Proteins 030217 neurology & neurosurgery Developmental Biology Lipoprotein |
| Zdroj: | Journal of cell science |
| ISSN: | 1477-9129 0950-1991 |
| Popis: | Summary The Drosophila tracheal system is a useful model for dissecting the molecular mechanisms controlling the assembly and expansion of tubular organs. We have identified microsomal triacylglycerol transfer protein (MTP) as a new player involved in the lumen expansion in unicellular tubes. MTP is an endoplasmic reticulum resident protein that can transfer triglycerides and phospholipids between membranes in vitro. MTP lipid transfer activity is crucial for the assembly and secretion of apoB family lipoproteins, which are carriers of lipids between different tissues. Here we describe an unexpected role of MTP in tracheal development, which we postulate to be independent of its known function in lipoprotein secretion. We propose that, in tracheal cells, MTP is involved in regulation of de novo apical membrane delivery to the existing lumen and thus promotes proper expansion of the larval tracheal system. |
| Databáze: | OpenAIRE |
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