An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance

Autor:	Stefanie N. Vogel, B E Henricson, R Neta
Rok vydání:	1991
Předmět:	Lipopolysaccharides medicine.medical_specialty Lipopolysaccharide medicine.drug_class Sialoglycoproteins Immunology Biology Microbiology Immune tolerance Mice chemistry.chemical_compound Internal medicine Immune Tolerance medicine Animals Antagonist Granulocyte-Macrophage Colony-Stimulating Factor Proteins Interleukin Receptor antagonist Colony-stimulating factor Recombinant Proteins Endotoxins Mice Inbred C57BL Interleukin 1 Receptor Antagonist Protein Infectious Diseases Endocrinology Granulocyte macrophage colony-stimulating factor Interleukin 1 receptor antagonist chemistry Parasitology Interleukin-1 Research Article medicine.drug
Zdroj:	Infection and Immunity. 59:1188-1191
ISSN:	1098-5522 0019-9567
DOI:	10.1128/iai.59.3.1188-1191.1991
Popis:	In this report, administration of a recombinant interleukin-1 receptor antagonist protein to mice was found to inhibit induction of colony-stimulating factor as well as induction of early endotoxin tolerance by lipopolysaccharide. These findings provide direct evidence that interleukin-1 is an intermediate in these two lipopolysaccharide-induced phenomena.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82f3d3023eb4b5940026c0d71baca9e https://doi.org/10.1128/iai.59.3.1188-1191.1991 Zobrazit plný text záznamu