Angiotensin-Converting Enzyme Gene Polymorphism in Children with Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings
| Autor: | Mehryar Mehrkash, Neamatollah Ataei, Mohammad Vasei, Mahshid Hesami, Niloofar Hajizadeh, Safoora Hooshmand, Mastaneh Moghtaderi, Maryam Monajemzadeh, Reza Shahsiah, Narjes Soleimanifar, Behnaz Bazargani, Reza Khorvash, Faezeh Javadi Larijani, Parin Tanzifi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Nephrotic Syndrome Adolescent Genotype Biopsy 030232 urology & nephrology 030204 cardiovascular system & hematology Peptidyl-Dipeptidase A Polymorphism Single Nucleotide Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Renin–angiotensin system Medicine Humans Genetic Predisposition to Disease Child medicine.diagnostic_test biology business.industry Infant Angiotensin-converting enzyme General Medicine medicine.disease Angiotensin II Real-time polymerase chain reaction Endocrinology Child Preschool Pediatrics Perinatology and Child Health biology.protein Disease Progression Female Gene polymorphism business Nephrotic syndrome |
| Zdroj: | Fetal and pediatric pathology. 36(4) |
| ISSN: | 1551-3823 |
| Popis: | Objective: Angiotensin converting enzyme (ACE) converts angiotensin I into angiotensin II. The ACE gene shows an I/D polymorphism, which correlates with ACE concentrations. The aim of this study is to evaluate the distribution of the ACE I/D genotype in children with idiopathic nephrotic syndrome (INS) and healthy controls and study the effect of this polymorphism on clinical and pathologic findings. Methods: ACE gene I/D polymorphism of 104 patients with INS and 119 controls were determined. Results: The DD, ID, and II genotypes were found in 58.7%, 22.1%, and 19.2% of the patients, and in 79.8%, 2.5%, and 17.6% of controls, respectively (p > 0.05). The ID genotype was seen more frequently in patients resistant to treatment. Conclusion: The observed differences with previous reports suggest the influence of the genetic background on disease course. The ACE I/D gene polymorphism's role seems to be more important in renal disease progression than susceptibility. |
| Databáze: | OpenAIRE |
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