Effects of Endothelial Nitric Oxide Synthase, Interleukin-6 Gene Polymorphisms and Asymmetric Dimethylarginine Levels on Risk Factors and Lesion Sites in Peripheral Artery Disease
| Autor: | AY Balci, AK Tuygun, A Tuygun, Y Şensöz, B Ketenci, N Yurtseven, AR Karaci, Ibrahim Yekeler, M Kizilay, M Keser |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Nitric Oxide Synthase Type III DNA Mutational Analysis Arginine Biochemistry Lesion chemistry.chemical_compound Risk Factors Enos Surveys and Questionnaires Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Allele Interleukin 6 Peripheral Vascular Diseases Genetics Polymorphism Genetic Models Genetic biology Interleukin-6 business.industry Biochemistry (medical) Interleukin Cell Biology General Medicine Middle Aged biology.organism_classification Endocrinology chemistry biology.protein Female Gene polymorphism medicine.symptom Asymmetric dimethylarginine business |
| Zdroj: | Journal of International Medical Research. 37:1003-1010 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323000903700404 |
| Popis: | This study investigated risk factors for atherosclerosis and their relationship with lesion sites. Patients ( n = 160) with peripheral artery disease (PAD) completed a questionnaire regarding risk factors for PAD. Endothelial nitric oxide synthase (eNOS) and interleukin (IL)-6 gene polymorphisms and asymmetric dimethylarginine (ADMA) levels were measured. Patients with coronary artery disease had significantly higher ratios of eNOS T/C and C/C genotypes, which include the C allele, than the T/T genotype. The IL-6 gene polymorphism distribution ratios for patients with over four risk factors were significantly different compared with other patients, with a higher rate of the C/C genotype. ADMA levels did not show any significant relationship to risk factors or polymorphism. Levels were, however, slightly higher in femoral lesion sites. The results support a model in which the C/C genotype of eNOS and IL-6 gene polymorphisms promote PAD development. The eNOS C/C genotype may have an independent effect, whereas the effects of the IL-6 C/C genotype are seen in conjunction with other risk factors. |
| Databáze: | OpenAIRE |
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