Alzheimer's disease and immunotherapy: what is wrong with clinical trials?
| Autor: | Kuniko Kohyama, Yoh Matsumoto |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Immunology Vaccine trial amyloid cascade theory Immunotherapy Disease Review medicine.disease Vaccine therapy amyloid-beta DNA vaccination Clinical trial Aβ peptide vaccine Immunization monoclonal antibody medicine Immunology and Allergy Dementia immunotherapy tau Intensive care medicine business |
| Zdroj: | Immunotargets and Therapy |
| ISSN: | 2253-1556 |
| Popis: | Alzheimer's disease (AD) is characterized by progressive neurodegeneration and is the most common cause of dementia. Immunotherapy has recently been regarded as a potential treatment for AD. This stems from the fact that the clinical and pathological findings from the active AD vaccine trial suggests that such vaccine therapy may be effective for AD. However, this trial was halted because of the occurrence of meningoencephalitis in some patients. Avoiding excessive immune reaction is necessary for the success of vaccine therapy. For this purpose, adjuvant-free vaccine therapies (eg, passive immunization or DNA vaccines) are currently under investigation. However, the results of clinical trials employing both active and passive anti-amyloid-beta immunotherapy have been unsatisfactory. In this article, we will analyze the reasons for the limited efficacy of currently available immunotherapies and discuss the effectiveness of new vaccine therapies. Finally, we will speculate on the possibility of its clinical application. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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