Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits
| Autor: | Zhi-Qiang Shen, Juha Kantanen, Peng-Cheng Wan, Johannes A. Lenstra, Meng-Hua Li, Min Shen, James Kijas, Ping Zhou, Ji Yang, Juan Deng, EEr Hehua, Yong-Lin Yang, Olivier Hanotte, Jian-Lin Han, Yang Jingquan, Xinhua Wang, Zhang Yunsheng, Liu Changbin, Mostafa Dehghani-Qanatqestani, Ondřej Štěpánek, Ali Esmailizadeh, C. Weimann, Pi Wenhui, Feng-Hua Lv, David W. Coltman, Lei Gao, Xin Li, Michael William Bruford, Ya-Xi Xu, Guangjian Liu, Feng Wang, Yan-Ling Ren, Xing-Long Xie, Agraw Amane, Joram M. Mwacharo, Kathiravan Periasamy, Hua Yang, Song-Song Xu, Georg Erhardt, Hosein Salehian-Dehkordi |
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| Přispěvatelé: | Sub Cellular Protein Chemistry, One Health Toxicologie, Afd Pharmacology |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Candidate gene General Physics and Astronomy Breeding Linkage Disequilibrium 0302 clinical medicine Gene Frequency Sequencing Animal Husbandry lcsh:Science Ovis Platelet-Derived Growth Factor Multidisciplinary biology High-Throughput Nucleotide Sequencing Genomics Phenotype Female Agricultural genetics Genotype Science Animals Wild Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Species Specificity Genetic variation Genetics Animals Allele Selection Genetic Domestication Allele frequency Gene Alleles Sheep Domestic Sheep Whole Genome Sequencing Genetic Variation General Chemistry Sequence Analysis DNA biology.organism_classification 030104 developmental biology Evolutionary biology Mutation lcsh:Q 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications Li, X, Yang, J, Shen, M, Xie, X-L, Liu, G-J, Xu, Y-X, Lv, F-H, Yang, H, Yang, Y-L, Liu, C-B, Zhou, P, Wan, P-C, Zhang, Y-S, Gao, L, Yang, J-Q, Pi, W-H, Ren, Y-L, Shen, Z-Q, Wang, F, Deng, J, Xu, S-S, Salehian-Dehkordi, H, Hehua, E, Esmailizadeh, A, Dehghani-Qanatqestani, M, Štěpánek, O, Weimann, C, Erhardt, G, Amane, A, Mwacharo, J M, Han, J-L, Hanotte, O, Lenstra, J A, Kantanen, J, Coltman, D W, Kijas, J W, Bruford, M W, Periasamy, K, Wang, X-H & Li, M-H 2020, ' Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits ', Nature Communications, vol. 11, no. 1, pp. 2815 . https://doi.org/10.1038/s41467-020-16485-1 Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020) Nature Communications, 11. Nature Publishing Group |
| ISSN: | 2041-1723 |
| Popis: | Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitate our efforts towards further improvement. Here, we report the deep resequencing of 248 sheep including the wild ancestor (O. orientalis), landraces, and improved breeds. We explored the sheep variome and selection signatures. We detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, breeding, and selection. Furthermore, we found non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds. We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep through transcriptome, RT-PCR, qPCR, and Western blot analyses. Our results provide insights into the demographic history of sheep and a valuable genomic resource for future genetic studies and improved genome-assisted breeding of sheep and other domestic animals. Genetic resources for livestock are valuable for understanding their demography and past selection, and may inform future breeding programs and agricultural improvement. Here, the authors present deep resequencing of 248 wild and domestic sheep, with associated data and analysis. |
| Databáze: | OpenAIRE |
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