Insulin and glucagon relationships during aging in rats
| Autor: | Shigeaki Baba, Noboru Kobayashi, Tsutomu Kazumi, Katsuhiro Terashi, Gen Yoshino, Soichiro Morita |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Blood Glucose
Male Aging medicine.medical_specialty medicine.medical_treatment Glucagon Endocrinology Age groups Internal medicine Insulin Secretion medicine Animals Insulin Oral glucose tolerance business.industry Significant difference General Engineering Glucagon secretion Glucose Tolerance Test Plasma glucagon Rats Pentobarbital anesthesia business |
| Zdroj: | Endocrinologia Japonica. 26:325-329 |
| ISSN: | 2185-6370 0013-7219 |
| Popis: | Oral glucose tolerance tests were performed under pentobarbital anesthesia in 43 male Wistar rats 2 to 18 months of age in order to determine if insulin and glucagon secretion are altered with aging. Although any linear correlation was not demonstrated between aging and blood glucose, plasma insulin or glucagon levels, post-glucose levels of blood glucose were significantly suppressed and those of plasma glucagon were significantly elevated at 4 to 6 months of age. No significant difference was found between young (2 months of age) and aged rats (12 to 14 and 17 to 18 months of age) in either blood glucose or plasma insulin levels during oral glucose load. On the other hand, post-glucose plasma glucagon levels of the aged rats were significantly higher than those of the young ones. Furthermore, comparisons of various kinds of indices among the different age groups, such as insulinogenic index, insulin/glucagon and so forth during oral glucose tolerance tests also indicate the significant alteration of glucagon secretion during aging process. It is concluded from the present data that glucose tolerance does not apparently deteriorate during aging process in rats but that glucagon responses to oral glucose administration are elevated with aging. |
| Databáze: | OpenAIRE |
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