The effect of tenofovir in renal function in HIV-positive adult patients in the Roma health service area, Lesotho, southern Africa
| Autor: | Eltony Mugomeri, Dedré Olivier, Elmien van den Heever-Kriek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Univariate analysis
medicine.medical_specialty Tenofovir Adult patients business.industry Public Health Environmental and Occupational Health Human immunodeficiency virus (HIV) Renal function medicine.disease medicine.disease_cause World health Poster Sessions – Abstract P149 Health services Infectious Diseases Acquired immunodeficiency syndrome (AIDS) Internal medicine medicine business medicine.drug |
| Zdroj: | Journal of the International AIDS Society |
| ISSN: | 1758-2652 |
| Popis: | Introduction : The government of Lesotho introduced tenofovir disoproxil fumarate (TDF) for first-line antiretroviral treatment (ART), as recommended by the World Health Organization [ 1 ], in 2008. The use of TDF has been associated with renal toxicity [ 2 ]; furthermore, renal function outcomes following the use of TDF has not been studied at Roma Health Service Area (RHSA) in Lesotho. Lesotho is a small landlocked country surrounded by South Africa. The study used an analytical design to compare retrospective creatinine clearance (CrCl) data of 312 (64%) antiretroviral treatment naive adults exposed to TDF and 173 (36%) unexposed patients. Methods : Impaired renal function was defined as CrCl less than 50 mL/min calculated using the Cockcroft-Gault equation. The Ministry of Health and Social Welfare of Lesotho approved the study on 13 January 2012. The study included adult (excluding pregnant females) HIV patients enrolled on ART between December 2006 and December 2012 at St Joseph's Mission Hospital and at Nazareth Health Centre (RHSA). Patients at Nazareth Health Centre and at St Joseph's Mission Hospital made up 80% of the circa 4 116 HIV patients on ART. Only 485 patients met the set inclusion criteria. Results : In 56 patients (17.9%), TDF was found to be contraindicated. The use of TDF was marginally significant factor for renal toxicity (p=0.054) in univariate analysis, but was insignificant (p=0.122) in multivariate logistic analysis. Univariate (p 60 (p=0.004) were significantly associated with CrCl |
| Databáze: | OpenAIRE |
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