Thallium-201 scintigraphy in bone and soft-tissue tumors: a comparison of dynamic, early and delayed scans
| Autor: | Yoshifumi Sugawara, Makoto Kajihara, Kenshi Sakayama, Takatoshi Semba, Teruhito Mochizuki, Shigeru Nakata, Takashi Ochi, Takashi Fujii, Takanori Kikuchi |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Soft Tissue Neoplasm Time Factors Adolescent chemistry.chemical_element Bone Neoplasms Soft Tissue Neoplasms Scintigraphy Sensitivity and Specificity Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Thallium Child Radionuclide Imaging Aged Aged 80 and over Dynamic Scan medicine.diagnostic_test business.industry Soft tissue Washout Reproducibility of Results General Medicine Blood flow Middle Aged Image Enhancement Thallium 201 scintigraphy chemistry Female Radiology Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | Annals of nuclear medicine. 19(6) |
| ISSN: | 0914-7187 |
| Popis: | It has been reported that delayed scan of thallium-201 (201Tl) scintigraphy is useful for differentiating malignant tumors from benign lesions and for evaluating treatment response. However, physiological muscle uptake which usually increases in delayed scans, often makes it difficult to evaluate 201Tl uptake and its washout in bone and soft-tissue tumors. The purpose of this study was to evaluate whether the delayed scan is necessary and whether a dynamic scan is useful in the evaluation of bone and soft-tissue tumors.We studied 175 cases of bone and soft-tissue tumors (malignant 45, benign 130). Dynamic scans were acquired every 5 seconds for 10 minutes after 201Tl injection, and time activity curves (TACs) were generated by adaptive smoothing methods. Early and delayed scans were acquired at 10-15 minutes and 2 hours after injection. 201Tl images were visually interpreted and the radioactivity count ratio (T/N) of tumors to normal tissues and washout rate [WR = (early T/N - delayed T/N)/early T/N] were defined.When there were no 201Tl uptake in dynamic (n = 67) and early scans (n = 68), no tumor uptake was also appreciated in delayed scans, and all but two cases of negative scans were benign. In 107 lesions, although there were significant differences in T/Ns between malignant and benign lesions both on early scans (2.84 +/- 1.45 vs. 2.05 +/- 1.13, p0.05) and delayed scans (2.17 +/- 1.03 vs. 1.58 +/- 0.64, p0.05), there was a substantial overlap. The T/Ns decreased in delayed scans (i.e., WR0) in 100 of 107 cases due to increase of surrounding muscle uptake, and there was no difference in WR between malignant tumors and benign lesions (0.21 +/- 0.14 vs. 0.19 +/- 0.14).For evaluating bone and soft-tissue tumors, delayed scan had little clinical usefulness and it may be time consuming. Dynamic scan would be useful for demonstrating the differences between tumor blood flow and 201Tl uptake in tumors. |
| Databáze: | OpenAIRE |
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