How specificity for self-peptides shapes the development and function of regulatory T cells
| Autor: | Soyoung Oh, Cristina Cozzo Picca, Andrew J. Caton, Jan Erikson, Donald M. Simons, Malinda Aitken, Olivia A. Perng |
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| Rok vydání: | 2010 |
| Předmět: |
T cell
Immunology Receptors Antigen T-Cell Reviews chemical and pharmacologic phenomena Thymus Gland Biology Autoantigens T-Lymphocytes Regulatory Autoimmune Diseases Mice Immune system medicine Animals Humans Immunology and Allergy Avidity IL-2 receptor Transcription factor fungi T-cell receptor food and beverages FOXP3 hemic and immune systems Cell Biology Thymocyte medicine.anatomical_structure |
| Zdroj: | Journal of Leukocyte Biology. 88:1099-1107 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1189/jlb.0310183 |
| Popis: | Review discusses studies analyzing how the immune system generates Treg cells that can recognize self-peptides and prevent harmful autoimmune responses. The cataclysmic disease that develops in mice and humans lacking CD4+ T cells expressing the transcription factor Foxp3 has provided abundant evidence that Foxp3+CD4+ Tregs are required to suppress a latent autoreactivity of the immune system. There is also evidence for the existence of tissue-specific Tregs that can act to suppress regional autoimmune responses, suggesting that Tregs exert their effects, in part, through responding to self-peptides. However, how the immune system generates a repertoire of Tregs that is designed to recognize and direct regulatory function to self-peptides is incompletely understood. This review describes studies aimed at determining how T cell recognition of self-peptide(s) directs Treg formation in the thymus, including discussion of a modified “avidity” model of thymocyte development. Studies aimed at determining how TCR specificity contributes to the ability of Tregs to suppress autoimmune diseases are also discussed. |
| Databáze: | OpenAIRE |
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