Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors
| Autor: | Fred K. Tabung, Andrew T. Chan, Mingyang Song, Edward Giovannucci, Katharina Nimptsch, Dong-Hoon Lee, Hee Kyung Joh, Kana Wu, Jinhee Hur, Tobias Pischon, Walter C. Willett, Leandro Fórnias Machado de Rezende, Yoosoo Chang, Shuji Ogino, Kimmie Ng, Jung Eun Lee, Charles S. Fuchs, Xuehong Zhang, Yin Cao, Hyojee Joung, Chen Yuan, Jeffrey A. Meyerhardt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Calorie Time Factors Adenoma Adolescent Colonic Polyps Colorectal adenoma Added sugar Gastroenterology Risk Assessment Article Adenomatous Polyps Risk Factors Internal medicine medicine Humans Prospective Studies Sugar Early Detection of Cancer Sugar-Sweetened Beverages Hepatology business.industry Monosaccharides Age Factors Odds ratio Feeding Behavior Middle Aged medicine.disease Confidence interval United States Adolescent Behavior Taste Female business Colorectal Neoplasms Sugars Body mass index Precancerous Conditions |
| Zdroj: | Gastroenterology |
| Popis: | Background & aims Recent increasing trends in early-onset colorectal cancer (CRC) strongly supports that early-life diet is involved in CRC development. However, data are lacking on the relationship with high sugar intake during early life. Methods We prospectively investigated the association of adolescent simple sugar (fructose, glucose, added sugar, total sugar) and sugar-sweetened beverage (SSB) intake with CRC precursor risk in 33,106 participants of the Nurses' Health Study II who provided adolescent dietary information in 1998 and subsequently underwent lower gastrointestinal endoscopy between 1999 and 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression for clustered data. Results During follow-up, 2909 conventional adenomas (758 high-risk) and 2355 serrated lesions were identified (mean age at diagnoses, 52.2 ± 4.3 years). High sugar and SSB intake during adolescence was positively associated with risk of adenoma, but not serrated lesions. Per each increment of 5% of calories from total fructose intake, multivariable ORs were 1.17 (95% CI, 1.05–1.31) for total and 1.30 (95% CI, 1.06–1.60) for high-risk adenoma. By subsite, ORs were 1.12 (95% CI, 0.96–1.30) for proximal, 1.24 (95% CI, 1.05–1.47) for distal, and 1.43 (95% CI, 1.10–1.86) for rectal adenoma. Per 1 serving/day increment in SSB intake, ORs were 1.11 (95% CI, 1.02–1.20) for total and 1.30 (95% CI, 1.08–1.55) for rectal adenoma. Contrary to adolescent intake, sugar and SSB intake during adulthood was not associated with adenoma risk. Conclusions High intake of simple sugars and SSBs during adolescence was associated with increased risk of conventional adenoma, especially rectal adenoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|