Increased plasma dipeptidyl peptidase IV (DPP IV) activity and decreased DPP IV activity of visceral but not subcutaneous adipose tissue in impaired glucose tolerance rats induced by high-fat or high-sucrose diet
| Autor: | Kazuo Minakuchi, Youichi Sato, Kazuyoshi Kawazoe, Yasushi Kirino, Yutaka Nakahori, Takayuki Kamimoto |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Normal diet Dipeptidyl Peptidase 4 Subcutaneous Fat Pharmaceutical Science Adipose tissue Intra-Abdominal Fat Dipeptidyl peptidase Impaired glucose tolerance Eating Insulin resistance Dietary Sucrose Diabetes mellitus Internal medicine Glucose Intolerance medicine Animals Pharmacology Kidney Chemistry Body Weight General Medicine Glucose Tolerance Test medicine.disease Dietary Fats Rats Inbred F344 Rats Endocrinology medicine.anatomical_structure Organ Specificity RNA Subcutaneous adipose tissue |
| Zdroj: | Biologicalpharmaceutical bulletin. 32(3) |
| ISSN: | 0918-6158 |
| Popis: | Several studies have investigated whether dipeptidyl peptidase IV (DPP IV) activity is correlated to the severity of diabetes; however, it remains unclear. To investigate the roles of DPP IV activity in metabolic abnormalities, impaired glucose tolerance rats were produced using a high-fat (HF) or high-sucrose (HS) diet. HF diet-fed rats obviously exhibited impaired glucose tolerance, with increases in subcutaneous and epididymal fat mass, insulin resistance and dyslipidaemia. In rats fed a HS diet rather than a normal diet, lower body weight and fasting blood glucose were observed temporarily in the early period after HS diet feeding; however, impaired glucose tolerance was evoked to some extent with an increase in epididymal fat mass. Both HF and HS diet-fed rats showed significantly higher plasma DPP IV activity than normal diet-fed rats, in the order of HF diet>HS diet>normal diet. HF and HS diets did not significantly affect DPP IV activity and mRNA expression in the kidney. On the other hand, HF, but not HS, diet caused a significant decrease in DPP IV activity in the liver as compared to the control. Of note, both HF and HS diets caused a significant decrease in DPP IV activity in epididymal fat, even though they did not change DPP IV activity in subcutaneous fat. In conclusion, HF or HS diet-induced impaired glucose tolerance with visceral fat accumulation may be interrelated with increased plasma DPP IV activity and decreased DPP IV activity of visceral but not subcutaneous adipose tissue. |
| Databáze: | OpenAIRE |
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