Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines
| Autor: | A A Rayner, Arthur Weiss, Lewis L. Lanier, B T Gemlo, Joseph H. Phillips |
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| Rok vydání: | 1987 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Cytotoxicity Immunologic T cell receptor complex CD3 T-Lymphocytes Cytotoxicity Immunology Receptors Antigen T-Cell chemical and pharmacologic phenomena Receptors Fc Major histocompatibility complex Medical and Health Sciences Antibodies Cell Line Immunoglobulin Fab Fragments Cell surface receptor Immunologic Receptors Tumor Cells Cultured Immunology and Allergy 2.1 Biological and endogenous factors Humans Antigens Cultured biology Fc Inflammatory and immune system T-cell receptor hemic and immune systems Articles T-Cell Molecular biology Tumor Cells Cytolysis Thymocyte T-Lymphocyte Antigen Differentiation biology.protein Interleukin-2 |
| Zdroj: | The Journal of experimental medicine, vol 166, iss 5 The Journal of Experimental Medicine |
| Popis: | After culture in IL-2, thymocytes expressing either TCR-alpha/beta or -gamma/delta acquired the ability to lyse hematopoietic and solid tumor cell targets without deliberate immunization or apparent restriction by the MHC. Moreover, TCR-alpha/beta- and TCR-gamma/delta-bearing thymic cell lines demonstrated an essentially identical spectrum of cytolysis against several tumor cell targets. Cytotoxicity was not inhibited by antibodies against CD3 or CD2 and modulation of the CD3/TCR complex also failed to affect cytotoxicity. Thus, non-MHC-restricted cytotoxicity can be mediated by thymocytes with either TCR-alpha/beta or TCR-gamma/delta, but the TCR may not be responsible for target recognition. |
| Databáze: | OpenAIRE |
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