Delayed Treatment Response in a Neonate with Multisystem Langerhans Cell Histiocytosis Case report and review of literature
| Autor: | Sataroopa Mishra, Ankita Patel, Anirban Mandal, Amitabh Singh, Lavleen Singh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology medicine.medical_specialty Delayed Diagnosis Anemia Biopsy Anti-Inflammatory Agents lcsh:Medicine India Case Report Disease langerhans cell histiocytosis Vinblastine seborrheic dermatitis 03 medical and health sciences 0302 clinical medicine Langerhans cell histiocytosis Prednisone Medicine Humans Lung Skin medicine.diagnostic_test business.industry lcsh:R Infant Combination chemotherapy General Medicine Exanthema medicine.disease anemia Dermatology Antineoplastic Agents Phytogenic Histiocytosis Langerhans-Cell medicine.anatomical_structure 030220 oncology & carcinogenesis Langerhans Cells Skin biopsy Disease Progression Drug Therapy Combination business tachypnea 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Sultan Qaboos University Medical Journal, Vol 17, Iss 2, Pp 225-228 (2017) |
| ISSN: | 2075-0528 |
| Popis: | Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of the Langerhans cells, which are part of the mononuclear phagocytic system. The disorder varies in terms of the extent of the disease, its natural course and patient outcomes. While skin rashes are a common presentation of neonatal LCH, other systems or organs may also be involved. Delays in the diagnosis of neonatal LCH may occur due to its non-specific presentation and a lack of awareness of the condition among doctors. We report a two-month-old male neonate who presented to the Chacha Nehru Bal Chikitsalya hospital, New Delhi, India, in 2016 after the onset of pulmonary symptoms. He had been noted to have a generalised rash which had progressively worsened from 15 days of age. Following a skin biopsy and chest imaging, he was diagnosed with multisystem LCH with risk organ involvement. There was a delayed response to combined chemotherapy with no major side-effects. |
| Databáze: | OpenAIRE |
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