Successful Rituximab Treatment in Thrombotic Thrombocytopenic Purpura Patients Complicated by Other Autoimmune Disorders: Two Case Reports
| Autor: | Satoko Osanai, Akihito Shinohara, Maya Kobayashi, Michiko Ryuzaki, Midori Ishiyama, Junji Tanaka, Norina Tanaka, Shoko Oshima, Kentaro Yoshinaga, Yuki Izuka, Masayuki Shiseki, Megumi Oishi, Hiroshi Kazama, Shotaro Hagiwara, Aya Watanabe |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Early introduction Thrombotic thrombocytopenic purpura Corticosteroid treatment Case Report Autoimmune hepatitis 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences rituximab 0302 clinical medicine Recurrence hemic and lymphatic diseases Internal medicine Internal Medicine medicine Humans thrombotic thrombocytopenic purpura Objective response Purpura Thrombocytopenic Idiopathic Plasma Exchange Purpura Thrombotic Thrombocytopenic autoimmune hepatitis business.industry General Medicine medicine.disease ADAMTS13 Immune thrombocytopenia immune thrombocytopenia 030211 gastroenterology & hepatology Rituximab business medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.6387-20 |
| Popis: | We herein report two cases of thrombotic thrombocytopenic purpura (TTP) complicated by other autoimmune disorders, autoimmune hepatitis and immune thrombocytopenia, respectively. In both cases, corticosteroids were continuously administered for the treatment of preceding autoimmune disorders. However, a sufficient objective response for TTP was not obtained by plasma exchange and corticosteroid treatment. Once a week rituximab (375 mg/m2) treatment for 4 times was initiated within 2 weeks from the diagnosis. Both patients achieved a sufficient response, and have never had any recurrence as of the last follow-up dates. The early introduction of rituximab could be an effective treatment option in TTP patients complicated with other autoimmune disorders. |
| Databáze: | OpenAIRE |
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