Preferential campesterol incorporation into various tissues in apolipoprotein E*3-Leiden mice consuming plant sterols or stanols
| Autor: | Ariënne de Jong, Oscar L. Volger, Jogchum Plat, Hans M.G. Princen, Ronald P. Mensink |
|---|---|
| Přispěvatelé: | Humane Biologie, Metamedica, RS: NUTRIM - R1 - Metabolic Syndrome, TNO Kwaliteit van Leven |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty campesterol Biomedical Research Endocrinology Diabetes and Metabolism Campesterol animal experiment tissue distribution Apolipoprotein E3 Sitosterols Mice Transgenic Biology Intestinal absorption animal tissue chemistry.chemical_compound Mice Endocrinology Internal medicine medicine polycyclic compounds Animals controlled study mouse phytosterol nonhuman concentration (parameters) Cholesterol Phytosterol Osmolar Concentration stanol ester article cholesterol Phytosterols Sterol Stanol ester Diet female chemistry sitosterol priority journal diet supplementation lipids (amino acids peptides and proteins) |
| Zdroj: | Metabolism-Clinical and Experimental, 57(9), 1241-1247. W B Saunders Co-Elsevier Inc Metabolism: Clinical and Experimental, 9, 57, 1241-1247 |
| ISSN: | 0026-0495 |
| Popis: | Intestinal absorption of plant sterols and stanols is much lower as compared with that of cholesterol; and therefore, serum concentrations are low. Circulating plant sterols and stanols are incorporated into tissues. However, hardly any data are available about tissue distributions of individual plant sterols and stanols, particularly in relation to their serum concentrations. We therefore fed female apolipoprotein E*3-Leiden mice a control diet, a plant sterol-enriched diet (1g/100 g diet), or a plant stanol-enriched diet (1g/100 g diet) for 8 weeks. In the sterol group, serum cholesterol-standardized campesterol and sitosterol concentrations were, respectively, 8 and 7 times higher as compared with those in the control group. Consequently, the serum campesterol-sitosterol ratio remained essentially unchanged. Cholesterol-standardized plant sterol concentrations increased significantly in all analyzed tissues, except brain. However, the campesterol-sitosterol ratio also increased in all tissues (except in liver and spleen), suggesting that campesterol is preferentially incorporated over sitosterol in those tissues. For the stanol group, serum plant stanol concentrations also increased; but the increase was but less pronounced. We conclude that, in apolipoprotein E*3-Leiden mice, campesterol is preferentially incorporated into most tissues over sitosterol, which cannot be deduced from changes in serum concentrations. © 2008 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect