Effect of Ethanol and Its Metabolites on Microtubule Formation
| Autor: | Michael F. Sorrell, Richard B. Jennett, Dean J. Tuma |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Pharmacology
Ethanol Chemistry Sodium Acetaldehyde chemistry.chemical_element macromolecular substances General Medicine Acetates Inhibitory postsynaptic potential Microtubules chemistry.chemical_compound Biochemistry Polymerization Tubulin Microtubule Animals Cattle Sodium acetate Microtubule nucleation |
| Zdroj: | Pharmacology. 21:363-368 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000137453 |
| Popis: | Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetyldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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