Expert Consensus on Optimal Acquisition and Development of the International Bowel Ultrasound Segmental Activity Score [IBUS-SAS]: A Reliability and Inter-rater Variability Study on Intestinal Ultrasonography in Crohn’s Disease
| Autor: | Frauke Petersen, Floris de Voogd, Kim Nylund, Cathy Lu, Britt Christensen, Carolina Palmela, Rune Wilkens, Rose Vaughan, Dan Carter, Giovanni Maconi, Torsten Kucharzik, Christian Maaser, Mariangela Allocca, Kerri L. Novak |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Consensus Delphi Technique Doppler echocardiography 03 medical and health sciences 0302 clinical medicine Crohn Disease Ultrasound medicine Medical imaging Humans Reliability (statistics) Ultrasonography AcademicSubjects/MED00260 Crohn's disease reliability medicine.diagnostic_test business.industry activity index Gastroenterology Reproducibility of Results Expert consensus Original Articles General Medicine medicine.disease Eccojc/1120 monitoring Inter-rater reliability 030104 developmental biology 030211 gastroenterology & hepatology Radiology business |
| Zdroj: | Journal of Crohn's & Colitis |
| ISSN: | 1876-4479 1873-9946 |
| DOI: | 10.1093/ecco-jcc/jjaa216 |
| Popis: | Background and Aims Intestinal ultrasound [IUS] is an accurate, patient-centreed monitoring tool that objectively evaluates Crohn’s disease [CD] activity. However no current, widely accepted, reproducible activity index exists to facilitate consistent IUS identification of inflammatory activity. The aim of this study is to identify key parameters of CD inflammation on IUS, evaluate their reliability, and develop an IUS index reflecting segmental activity. Methods There were three phases: [1] expert consensus Delphi method to derive measures of IUS activity; [2] an initial, multi-expert case acquisition and expert interpretation of 20 blinded cases, to measure inter-rater reliability for individual measures; [3] refinement of case acquisition and interpretation by 12 international experts, with 30 blinded case reads with reliability assessment and development of a segmental activity score. Results Delphi consensus: 11 experts representing seven countries identified four key parameters including: [1] bowel wall thickness [BWT]; [2] bowel wall stratification; [3] hyperaemia of the wall [colour Doppler imaging]; and [4] inflammatory mesenteric fat. Blind read: each variable exhibited moderate to substantial reliability. Optimal, standardised image and cineloop acquisition were established. Second blind read and score development: intra-class correlation coefficient [ICC] for BWT was almost perfect at 0.96 [0.94–0.98]. All four parameters correlated with the global disease activity assessment and were included in the final International Bowel Ultrasound Segmental Activity Score with almost perfect ICC (0.97 [0.95–0.99, p Conclusions Using expert consensus and standardised approaches, identification of key activity measurements on IUS has been achieved and a segmental activity score has been proposed, demonstrating excellent reliability. |
| Databáze: | OpenAIRE |
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