Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
| Autor: | Donald R. Senger, Carole A. Perruzzi, Harold F. Dvorak, Stephen J. Galli, V. Susan Harvey, Ann M. Dvorak |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Multidisciplinary
Guinea Pigs Ascites Vascular permeability Vascular Endothelial Growth Factor Family Neoplasms Experimental Biology medicine.disease Molecular biology In vitro Guinea pig Capillary Permeability Mice Permeability (electromagnetism) Cricetinae Immunology medicine Neoplasm Animals Ascitic Fluid Secretion medicine.symptom |
| Zdroj: | Science (New York, N.Y.). 219(4587) |
| ISSN: | 0036-8075 |
| Popis: | Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|