An 'Anaplastic' Kaposi's Sarcoma Mimicking a Stewart-Treves Syndrome. A Case Report and a Review of Literature
| Autor: | Patrice Morand, N. Pinel, Sylvie Lantuejoul, Julie Charles, Isabelle Templier, Marie-Thérèse Leccia, Dimitri Salameire |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Hemangiosarcoma Context (language use) Dermatology Pathology and Forensic Medicine Diagnosis Differential Viral Proteins Biomarkers Tumor medicine Humans Angiosarcoma Lymphedema Sarcoma Kaposi Kaposi's sarcoma Stewart–Treves syndrome business.industry Cancer Lymphangiosarcoma DNA Neoplasm Syndrome General Medicine Middle Aged medicine.disease Herpesvirus 8 Human Female Lymphadenectomy Sarcoma business |
| Zdroj: | The American Journal of Dermatopathology. 30:265-268 |
| ISSN: | 0193-1091 |
| Popis: | Cutaneous angiosarcoma (AGS) developing in a lymphedematous arm, after lymphadenectomy in the context of breast cancer, is the definition of the classical Stewart-Treves syndrome. Like AGS, many tumors such as Kaposi's sarcoma (KS) could develop in chronic lymphedema. We describe the case of a 50-year-old woman who presented with several nodules on the left lymphedematous arm evocative of a Stewart-Treves syndrome, 2 years after a left mastectomy and a homolateral lymphadenectomy. The histological examination revealed an atypical vascular proliferation suggesting AGS, but endothelial atypical cells nuclei were strongly stained by herpes human virus 8 antibody. The final diagnosis was an "anaplastic" KS mimicking a Stewart-Treves syndrome. The total regression of the lesion was obtained by elastic contention and intradermic liposomal doxorubicin. "Anaplastic" KS is a rare histological form of nodular KS, which mimics a cutaneous AGS but classically expresses herpes human virus 8. It is essential to know about this entity, particularly in a lymphedematous arm, to avoid aggressive treatment such as amputation. |
| Databáze: | OpenAIRE |
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