Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Central Saudi Arabia cohort of the A 1 chieve study
| Autor: | Najim Abdulwahid, Syed Salman Ali, Muhamed Shahed Omar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Insulin Analogue endocrine system diseases type 2 diabetes mellitus A1chieve study Endocrinology Diabetes and Metabolism medicine.medical_treatment insulin analogues Type 2 diabetes lcsh:Diseases of the endocrine glands. Clinical endocrinology Insulin aspart Endocrinology A 1 chieve study Internal medicine medicine lcsh:RC799-869 Insulin detemir lcsh:RC648-665 business.industry Insulin Type 2 Diabetes Mellitus nutritional and metabolic diseases medicine.disease Biphasic insulin aspart Cohort Optometry Original Article lcsh:Diseases of the digestive system. Gastroenterology business Central Saudi Arabia hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Indian Journal of Endocrinology and Metabolism, Vol 17, Iss 8, Pp 445-448 (2013) Indian Journal of Endocrinology and Metabolism |
| ISSN: | 2230-9500 2230-8210 |
| Popis: | Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. Materials and Methods: Data was collected at baseline, at 12 weeks and at 24 weeks. This short communication presents the results for patients enrolled from Central Saudi Arabia. Results: A total of 2819 patients were enrolled in the study. Four different insulin analogue regimens were used in the study. Study patients had started on or were switched to biphasic insulin aspart (n = 1100), insulin detemir (n = 1156), insulin aspart (n = 34), basal insulin plus insulin aspart (n = 314) and other insulin combinations (n = 170). At baseline glycaemic control was poor for both insulin naïve (mean HbA 1 c: 9.9%) and insulin user (mean HbA 1 c: 9.8%) groups. After 24 weeks of treatment, both the groups showed improvement in HbA 1 c (insulin naïve: −2.6%, insulin users: −2.5%). SADRs including major hypoglycaemic events did not occur in the study patients. Conclusion: Starting or switching to insulin analogues was associated with improvement in glycaemic control with a low rate of hypoglycaemia. |
| Databáze: | OpenAIRE |
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