Borrelia burgdorferi uridine kinase: an enzyme of the pyrimidine salvage pathway for endogenous use of nucleotides
| Autor: | I. Saint Girons, A.M Gilles, Caroline Boursaux-Eude, Danielle Margarita, Octavian Bârzu |
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| Rok vydání: | 2006 |
| Předmět: |
Operon
Molecular Sequence Data Biology Microbiology Uridine kinase chemistry.chemical_compound Borrelia burgdorferi Group Borrelia Genetics Nucleotide Amino Acid Sequence Cloning Molecular Borrelia burgdorferi Molecular Biology Gene Peptide sequence chemistry.chemical_classification Methionine bacterial infections and mycoses biology.organism_classification Molecular biology Pyrimidines Biochemistry chemistry Uridine Kinase |
| Zdroj: | FEMS Microbiology Letters. 151:257-261 |
| ISSN: | 0378-1097 |
| DOI: | 10.1111/j.1574-6968.1997.tb12579.x |
| Popis: | The 621 bp udk gene encoding Borrelia burgdorferi potential uridine kinase, involved in the pyrimidine salvage pathway, was cloned and sequenced. The B. burgdorferi protein has a molecular mass of 24 kDa in sodium dodecyl sulfate-polyacrylamide gel. The N-terminal sequence of the protein, Ala-Lys-Ile-Ile, is identical to that predicted but lacks N-terminal methionine. udk is located at around 15 kb from the left telomere and forms an operon with an upstream ORF. A likely hypothesis for the role of the pyrimidine salvage pathway is the sole use of endogenous nucleotides for Borrelia. |
| Databáze: | OpenAIRE |
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