Neuroprotective Effect of Vascular Endothelial Growth Factor on Motoneurons of the Oculomotor System
| Autor: | Angel M. Pastor, Silvia Silva-Hucha, Sara Morcuende |
|---|---|
| Přispěvatelé: | Universidad de Sevilla. Departamento de Fisiología, Universidad de Sevilla. BIO297: Laboratorio de Fisiología y Plasticidad Neuronal, Ministerio de Ciencia e Innovación (MICIN). España, Agencia Estatal de Investigación. España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Junta de Andalucía |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nervous system
Vascular Endothelial Growth Factor A amyotrophic lateral sclerosis medicine.medical_treatment trophic factors Review lcsh:Chemistry chemistry.chemical_compound lcsh:QH301-705.5 Spectroscopy Motor Neurons musculoskeletal neural and ocular physiology Neurodegeneration neurodegeneration Neurodegenerative Diseases General Medicine musculoskeletal system VEGF Computer Science Applications Vascular endothelial growth factor axotomy medicine.anatomical_structure Neuroprotective Agents Oculomotor Nuclear Complex Brainstem motoneurons Axotomy tissues Biology Neuroprotection Catalysis Inorganic Chemistry Paracrine signalling medicine Animals Humans Physical and Theoretical Chemistry Autocrine signalling Molecular Biology oculomotor system Organic Chemistry fungi medicine.disease Vascular Endothelial Growth Factor Receptor-2 lcsh:Biology (General) lcsh:QD1-999 chemistry nervous system Neuroscience Brain Stem |
| Zdroj: | idUS: Depósito de Investigación de la Universidad de Sevilla Universidad de Sevilla (US) International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 814, p 814 (2021) idUS. Depósito de Investigación de la Universidad de Sevilla instname |
| Popis: | Vascular endothelial growth factor (VEGF) was initially characterized as a potent angiogenic factor based on its activity on the vascular system. However, it is now well established that VEGF also plays a crucial role as a neuroprotective factor in the nervous system. A deficit of VEGF has been related to motoneuronal degeneration, such as that occurring in amyotrophic lateral sclerosis (ALS). Strikingly, motoneurons of the oculomotor system show lesser vulnerability to neurodegeneration in ALS compared to other motoneurons. These motoneurons presented higher amounts of VEGF and its receptor Flk-1 than other brainstem pools. That higher VEGF level could be due to an enhanced retrograde input from their target muscles, but it can also be produced by the motoneurons themselves and act in an autocrine way. By contrast, VEGF’s paracrine supply from the vicinity cells, such as glial cells, seems to represent a minor source of VEGF for brainstem motoneurons. In addition, ocular motoneurons experiment an increase in VEGF and Flk-1 level in response to axotomy, not observed in facial or hypoglossal motoneurons. Therefore, in this review, we summarize the differences in VEGF availability that could contribute to the higher resistance of extraocular motoneurons to injury and neurodegenerative diseases. Ministerio de Ciencia e Innovación de España (MCI), Agencia Estatal de Investigación de España (AEI) y Fondo Europeo de Desarrollo Regional (FEDER)-BFU2015-64515-P y PGC2018-094654-B-100 Junta de Andalucía-BIO-297 |
| Databáze: | OpenAIRE |
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