The management of numerous carcinomatous sequelae of human papilloma virus in an allogeneic stem cell transplant patient with chronic graft versus host disease

Autor: Courtney Gwinn, Amanda Williams, Philip Fleckman, Jayasri G. Iyer, Michi M. Shinohara
Rok vydání: 2019
Předmět:
squamous cell carcinoma
acute myelogenous leukemia
mucosal squamous cell carcinoma
Case Report
Dermatology
head and neck squamous cell carcinoma
GVHD
graft versus host disease
SCC
squamous cell carcinoma
SCCIS
squamous cell carcinoma in situ
verruca vulgaris
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
human papilloma virus
Immunity
graft versus host disease
warts
Medicine
Common warts
allogeneic stem cell transplant
cSCC
cutaneous squamous cell carcinoma
cutaneous
business.industry
Incidence (epidemiology)
HPV infection
medicine.disease
HPV
human papilloma virus
Head and neck squamous-cell carcinoma
Transplantation
cGVHD
chronic graft versus host disease
Graft-versus-host disease
allo-SCT
allogeneic stem cell transplantation
030220 oncology & carcinogenesis
Immunology
immunodeficient
Stem cell
business
Zdroj: JAAD Case Reports
ISSN: 2352-5126
DOI: 10.1016/j.jdcr.2018.11.010
Popis: The clinical manifestations of human papilloma virus (HPV) infection are vast, ranging from common warts to squamous cell carcinomas (SCCs). Immunodeficient populations are particularly susceptible to HPV infection in part because of deficiencies of cell-mediated immunity and diminished production of neutralizing antibodies.1 In particular, recipients of allogenic stem cell transplantation (allo-SCT) exhibit an increased risk for cutaneous SCC (cSCC) development, with a 20-year posttransplant incidence of 3.4%.2 Patients that have chronic graft versus host disease (cGVHD) are even more dramatically affected, with a risk of cSCC 5 times higher than that of the general population.3
Databáze: OpenAIRE
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