Histopathological changes in the gastrointestinal tract due to drugs: an update for the surgical pathologist (part I of II)
| Autor: | Amy J. Wendel Spizcka, Sonia Gatius Caldero, Shu Yuan Xiao, Dora Lam-Himlin, Giovanni De Petris, Longwen Chen, Bal M. Dhungel |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal tract business.industry Gastrointestinal Diseases Pathology Surgical Anti-Inflammatory Agents Non-Steroidal MEDLINE Ipilimumab Clinical correlation Pathology and Forensic Medicine Surgery Surgical pathology Gastrointestinal Tract medicine Humans Medical team Anatomy Intensive care medicine business Pathological Drug effect medicine.drug |
| Zdroj: | International journal of surgical pathology. 22(2) |
| ISSN: | 1940-2465 |
| Popis: | Abnormalities of the gastrointestinal (GI) tract due to drugs (AGIDs) are numerous and have significant impact. The aim of this narrative review is to help the practicing surgical pathologist recognize selected AGIDs. The adverse drug effects presented were chosen with an emphasis on recent and significant pathological and clinical contributions. The selection was based on a thorough review of the PUBMED-based literature and on the authors’ opinions and experience. In the first part of the review, diagnostic abnormalities due to crystals (eg, iron, biphosphonates, nonsystemic drugs), mitosis arresting drugs (colchicine, taxanes), and biological agents, especially ipilimumab, are discussed. Some AGIDs’ histopathologic features can be easily recognized. It is however the clinical correlation that in many cases of AGIDs will provide the necessary support for a drug effect diagnosis. The identification of AGIDs requires heightened awareness of the medical team in which close collaboration of pathologists and clinicians cannot be overemphasized. |
| Databáze: | OpenAIRE |
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