A cytostatic drug from the class of triazine derivatives:Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Autor:	Olga V. Mikolaichuk, Elena A. Popova, Alexandra V. Protas, Ilnaz T. Rakipov, Dmitry A. Nerukh, Andrey V. Petrov, Nikolay A. Charykov, Sergei V. Ageev, Grigorii V. Tochilnikov, Iulia G. Zmitrichenko, Aleksandr N. Stukov, Konstantin N. Semenov, Vladimir V. Sharoyko
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Materials Chemistry Physical and Theoretical Chemistry Condensed Matter Physics Spectroscopy Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials
ISSN:	1873-3166
Popis:	We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b811bbbb806e74e91dc6b974ce709081 https://publications.aston.ac.uk/id/eprint/43735/2/Mikolaichuk_et_al_Dioxadet_physchem_cytotoxic_drug_triazine_derivative_class_Article_Manuscript.pdf Zobrazit plný text záznamu Full Text from ScienceDirect