Hypercalcemia and acute kidney injury induced by eldecalcitol in patients with osteoporosis: a case series of 32 patients at a single facility

Autor:	Shunsuke Yamada, Kazuhiko Tsuruya, Toshiaki Nakano, Taro Kamimura, Hideaki Oka, Atsumi Harada, Seishi Aihara
Rok vydání:	2019
Předmět:	Male Vitamin medicine.medical_specialty Osteoporosis 030232 urology & nephrology 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Japan Internal medicine medicine Humans In patient eldecalcitol Vitamin D Aged Retrospective Studies Aged 80 and over Bone Density Conservation Agents business.industry Acute kidney injury hypercalcemia General Medicine Eldecalcitol medicine.disease osteoporosis Diseases of the genitourinary system. Urology Treatment Outcome acute kidney injury chemistry Nephrology Creatinine Clinical Study Calcium Female RC870-923 business Adverse drug reaction
Zdroj:	Renal Failure, Vol 41, Iss 1, Pp 88-97 (2019) Renal Failure
ISSN:	1525-6049 0886-022X
DOI:	10.1080/0886022x.2019.1578667
Popis:	Background: Eldecalcitol (ELD) is an active vitamin D3 analog that is widely used in Japan for the treatment of osteoporosis. The most common adverse drug reaction of ELD is hypercalcemia. However, few reports have focused on acute kidney injury (AKI) associated with ELD-induced hypercalcemia. Materials and methods: We retrospectively reviewed the medical records at our hospital for cases of hypercalcemia-induced AKI between April 2013 and February 2018. Among them, we focused on patients who developed AKI secondary to ELD-induced hypercalcemia. Results: Among 69 patients who developed hypercalcemia-induced AKI, 32 patients (46.4%) developed AKI associated with ELD-induced hypercalcemia. Their mean age was 82 ± 5 years, 97% of them were female, mean corrected serum calcium level was 12.2 ± 1.5 mg/dL, serum creatinine level was 2.5 ± 2.2 mg/dL, and estimated glomerular filtration rate was 23.9 ± 14.4 ml/min/1.73 m2 on admission. ELD administration was discontinued in all patients and some of them were treated with hydration with or without calcitonin, which was followed by a normalization of serum calcium level. Corrected serum calcium level on admission was significantly higher (p
Databáze:	OpenAIRE
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