(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase

Autor:	Emma L. Kaplan, Gary M. Coppola, Xilin Liu, Gregory Raymond Bebernitz, Donald Mark Sperbeck, Dominick DelGrande, Wieslawa Maniara, Leonard J. Brand, Suraj S. Shetty, Thomas Daniel Aicher, Robert C. Anderson, Charles F. Jewell, R. J. Lozito, Douglas C. Knorr, A. Islam, Chen Liu, Christine C. Vinluan, Jianping Gao, Robert J. Strohschein, William R. Mann, Carol J. Dragland, R. E. Walter
Rok vydání:	1999
Předmět:	Pyruvate dehydrogenase lipoamide kinase isozyme 1 Pyruvate dehydrogenase kinase Stereochemistry Administration Oral In Vitro Techniques Protein Serine-Threonine Kinases Pyruvate dehydrogenase phosphatase Chemical synthesis Structure-Activity Relationship Oral administration Drug Discovery Animals Humans Lactic Acid Enzyme Inhibitors Protein Kinase Inhibitors chemistry.chemical_classification biology Pyruvate Dehydrogenase Acetyl-Transferring Kinase Stereoisomerism Fibroblasts Amides Rats Enzyme Biochemistry chemistry Enzyme inhibitor biology.protein Molecular Medicine Propionates Branched-chain alpha-keto acid dehydrogenase complex Protein Kinases
Zdroj:	Journal of Medicinal Chemistry. 42:2741-2746
ISSN:	1520-4804 0022-2623
DOI:	10.1021/jm9902584
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80d109ec966714cd20d37ebc973dd61 https://doi.org/10.1021/jm9902584 Zobrazit plný text záznamu