Abbreviated breast magnetic resonance protocol: Value of high-resolution temporal dynamic sequence to improve lesion characterization

Autor: Benjamin Fedida, Isabelle Thomassin-Naggara, Emile Daraï, Guillaume Oldrini, Julie Poujol, Philippe Henrot, Isabelle Trop, Jacques Felblinger
Přispěvatelé: Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montréal (UdeM), Gynécologie-obstétrique et médecine de la reproduction - Maternité [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Rok vydání: 2017
Předmět:
Adult
medicine.medical_specialty
Population
Breast Neoplasms
[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine
Malignancy
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
Nipple discharge
Lesion
03 medical and health sciences
Young Adult
0302 clinical medicine
McNemar's test
Positive predicative value
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
medicine
Humans
Radiology
Nuclear Medicine and imaging
Breast
education
Aged
Retrospective Studies
Protocol (science)
education.field_of_study
business.industry
Reproducibility of Results
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
3. Good health
030220 oncology & carcinogenesis
Dynamic contrast-enhanced MRI
Female
Radiology
medicine.symptom
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: European Journal of Radiology
European Journal of Radiology, Elsevier, 2017, 95, pp.177-185. ⟨10.1016/j.ejrad.2017.07.025⟩
ISSN: 1872-7727
0720-048X
DOI: 10.1016/j.ejrad.2017.07.025⟩
Popis: International audience; To evaluate the added value of ULTRAFAST-MR sequence to an abbreviated FAST protocol in comparison with FULL protocol to distinguish benign from malignant lesions in a population of women, regardless of breast MR imaging indication. Materials and methods: From March 10th to September 22th, 2014, we retrospectively included a total of 70 consecutive patients with 106 histologically proven lesions (58 malignant and 48 benign) who underwent breast MR imaging for preoperative breast staging (n = 38), high-risk screening (n = 7), problem solving (n = 18), and nipple discharge (n = 4) with 12 time resolved imaging of contrast kinetics (TRICKS) acquisitions during contrast inflow interleaved in a regular high-resolution dynamic MRI protocol (FULL protocol). Two readers scored MR exams as either positive or negative and described significant lesions according to Bi-RADS lexicon with a TRICKS images (ULTRAFAST), an abbreviated protocol (FAST) and all images (FULL protocol). Sensitivity, specificity, positive and negative predictive values, and accuracy were calculated for each protocol and compared with McNemar's test. Results: For all readers, the combined FAST-ULTRAFAST protocol significantly improved the reading with a specificity of 83.3% and 70.8% in comparison with FAST protocol or FULL protocol, respectively, without change in sensitivity. By adding ULTRAFAST protocol to FAST protocol, readers 1 and 2 were able to correctly change the diagnosis in 22.9% (11/48) and 10.4% (5/48) of benign lesions, without missing any malignancy, respectively. Both interpretation and image acquisition times for combined FAST-ULTRAFAST protocol and FAST protocol were shorter compared to FULL protocol (p < 0.001). Conclusion: Compared to FULL protocol, adding ULTRAFAST to FAST protocol improves specificity, mainly in correctly reclassifying benign masses and reducing interpretation and acquisition time, without decreasing sensitivity.
Databáze: OpenAIRE
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