High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite

Autor: Akhilesh Pandey, Pasi K. Korhonen, Simone L. Reynolds, H. Lu, Andreas J. Stroehlein, Ehtesham Mofiz, Anil K. Madugundu, Neil D. Young, Anthony T. Papenfuss, Deepani D. Fernando, Santosh Renuse, Harsha Gowda, Ching-Seng Ang, Guangxu Ma, Sara Taylor, Tao Wang, Shivashankar H. Najaraj, Katja Fischer, Deborah C. Holt, Robin B. Gasser
Rok vydání: 2020
Předmět:
0301 basic medicine
Swine
Physiology
Ectoparasitic Infections
RC955-962
Disease
Sarcoptes scabiei
Genome
Biochemistry
Mass Spectrometry
Scabies
0302 clinical medicine
RNA interference
Medical Conditions
Genome Size
Arctic medicine. Tropical medicine
Allergies
Medicine and Health Sciences
Phylogeny
Skin
Genetics
Mites
integumentary system
Eukaryota
Genomics
Proteases
Enzymes
Nucleic acids
Infectious Diseases
Genetic interference
Epigenetics
Public aspects of medicine
RA1-1270
Research Article
Neglected Tropical Diseases
Arthropoda
030231 tropical medicine
Immunology
Sexually Transmitted Diseases
Excretion
Biology
Host-Parasite Interactions
03 medical and health sciences
Mite
medicine
Parasitic Diseases
Animals
Gene Prediction
Genome size
Public Health
Environmental and Occupational Health
Organisms
Tropical disease
Biology and Life Sciences
Proteins
Computational Biology
Allergens
biology.organism_classification
medicine.disease
Tropical Diseases
Genome Analysis
Invertebrates
030104 developmental biology
Parasitology
Enzymology
RNA
Clinical Immunology
Gene expression
Clinical Medicine
Physiological Processes
Zoology
Zdroj: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008720 (2020)
ISSN: 1935-2735
Popis: The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced ‘omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.
Author summary Scabies is a highly significant parasitic disease caused by the mite S. scabiei. This NTD has a major adverse impact in disadvantaged communities around the world, particularly when associated with secondary bacterial infections and clinical complications. Here we report the first high-quality genome and transcriptomic data for S. scabiei and explore molecular aspects of S. scabiei/scabies. This genome (56.6 Mb, encoding ~ 9,200 proteins) provides a solid foundation for fundamental investigations of the molecular biology of the mite, host-parasite interactions and disease processes as well as for translational research to develop new treatments, vaccines and diagnostic tests.
Databáze: OpenAIRE
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