Investigating Gut Permeability in Animal Models of Disease
| Autor: | Marcela Julio-Pieper, Marianela González-González, Camilo Díaz-Zepeda, Camila González-Arancibia, Johana Eyzaguirre-Velásquez, Javier A. Bravo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Intestinal permeability lcsh:QP1-981 Gut barrier Physiology Mini Review Disease Biology Bioinformatics medicine.disease gastrointestinal disorders lcsh:Physiology Pathophysiology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Physiology (medical) Gut permeability medicine gut barrier 030211 gastroenterology & hepatology permeability epithelium |
| Zdroj: | Frontiers in Physiology Frontiers in Physiology, Vol 9 (2019) |
| ISSN: | 1664-042X |
| Popis: | A growing number of investigations report the association between gut permeability and intestinal or extra-intestinal disorders under the basis that translocation of gut luminal contents could affect tissue function, either directly or indirectly. Still, in many cases it is unknown whether disruption of the gut barrier is a causative agent or a consequence of these conditions. Adequate experimental models are therefore required to further understand the pathophysiology of health disorders associated to gut barrier disruption and to develop and test pharmacological treatments. Here, we review the current animal models that display enhanced intestinal permeability, and discuss (1) their suitability to address mechanistic questions, such as the association between gut barrier alterations and disease and (2) their validity to test potential treatments for pathologies that are characterized by enhanced intestinal permeability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|