Predictive capacity of pre-donation GFR and renal reserve capacity for donor renal function after living kidney donation

Autor: Mieneke Rook, J. J. Homan van der Heide, Rutger J. Ploeg, W. J. van Son, Gerjan Navis, H. S. Hofker
Přispěvatelé: Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Other departments
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Urology
Renal function
kidney transplantation
BLOOD-PRESSURE
Kidney
urologic and male genital diseases
TERM
GLOMERULAR-FILTRATION-RATE
DISEASE
Donor Selection
Internal medicine
Living Donors
medicine
Humans
Immunology and Allergy
Pharmacology (medical)
EQUATIONS
Kidney transplantation
reproductive and urinary physiology
donor
SERUM CREATININE
NEPHRECTOMY
Donor selection
business.industry
urogenital system
TRANSPLANTATION
living donation
renal function
INFUSION
Middle Aged
medicine.disease
Nephrectomy
female genital diseases and pregnancy complications
Transplantation
Endocrinology
medicine.anatomical_structure
Renal physiology
renal reserve capacity
Female
business
FOLLOW-UP
Follow-Up Studies
Glomerular Filtration Rate
Kidney disease
Zdroj: American Journal of Transplantation, 6(7), 1653-1659. Wiley
American journal of transplantation, 6(7), 1653-1659. Wiley-Blackwell
ISSN: 1600-6135
Popis: Kidney transplantation from living donors is important to reduce organ shortage. Reliable pre-operative estimation of post-donation renal function is essential. We evaluated the predictive potential of pre-donation glomerular filtration rate (GFR) (iothalamate) and renal reserve capacity for post-donation GFR in kidney donors.GFR was measured in 125 consecutive donors (age 49 +/- 11 years; 36% male) 119 +/- 99 days before baseline GFR (GFR(b)) and 57 +/- 16 days after donation (GFR(post)). Reserve capacity was assessed as GFR during stimulation by low-dose dopamine (GFR(dopa)), amino acids (GFR(AA)) and both (GFR(max)).GFR(b) was 112 +/- 18, GFR(dopa) 124 +/- 22, GFR(AA) 127 +/- 19 and GFR(max) 138 +/- 22 mL/min. After donation, GFR remained 64 +/- 7%. GFR(post) was predicted by GFRb (R-2 = 0.54), GFR(dopa) (R-2 = 0.35), GFR(AA) (R-2 = 0.56), GFR(max) (R-2 = 0.55) and age (R-2 = - 0.22; p GFR allows a relatively reliable prediction of post-donation GFR, improving by taking age and stimulated GFR into account. Long-term studies are needed to further assess the prognostic value of pre-donation characteristics and to prospectively identify subjects with higher risk for renal function loss.
Databáze: OpenAIRE
Externí odkaz: