Anti-Inflammatory Effects of Novel Glycyrrhiza Variety Wongam In Vivo and In Vitro
| Autor: | Jeong Hoon Lee, Wonnam Kim, Yun-Mi Kang, Hyo-Jin An, Jong-Sik Jin, Jonghyun Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Allergy
Chemokine Technology medicine.drug_class QH301-705.5 QC1-999 Inflammation Pharmacology Immunoglobulin E Anti-inflammatory Proinflammatory cytokine In vivo mast cell activation medicine anaphylaxis General Materials Science novel Glycyrrhiza varieties Biology (General) Instrumentation QD1-999 Fluid Flow and Transfer Processes biology Process Chemistry and Technology Physics General Engineering medicine.disease biology.organism_classification allergy Engineering (General). Civil engineering (General) Computer Science Applications Chemistry inflammation biology.protein Glycyrrhiza Wongam medicine.symptom TA1-2040 |
| Zdroj: | Applied Sciences, Vol 11, Iss 10822, p 10822 (2021) Applied Sciences Volume 11 Issue 22 |
| ISSN: | 2076-3417 |
| Popis: | Licorice is the common name of Glycyrrhiza species, which is an important plant for edible and medicinal purposes however, Glycyrrhiza resources have become limited because of desertification, depletion of natural resources, and environmental restrictions. For this reason, a novel Glycyrrhiza variety named Wongam, a hybrid of G. glabra and G. uralensis, was developed by the Korea Rural Development Administration. To elucidate the antiallergic inflammatory effects of Wongam, we investigated its effects using a compound-48/80-induced anaphylaxis in vivo model and PMA/A23187-stimulated HMC-1 cells and immunoglobulin E (IgE)/DNP-stimulated RBL-2H3 cells in in vitro models. Wongam treatment reduced mortality and serum IgE levels and downregulated proinflammatory cytokines and chemokines in a compound-48/80-induced anaphylaxis mouse model. Wongam decreased histamine release and the expression of proinflammatory cytokines in HMC-1 and RBL-2H3 cells. Wongam treatment downregulated the expression of chemokines, T helper 2 cytokines, and cell surface antigens in PMA/A23187-stimulated HMC-1 cells. We confirmed that these effects were associated with the inhibition of the MAPK and NF-κB signaling pathways by Wongam. The present study suggests that Wongam ameliorates mast-cell-mediated allergic inflammatory responses by reducing mast cell activation and may serve as an effective agent for the prevention and treatment of allergic inflammatory responses. |
| Databáze: | OpenAIRE |
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