LIVER TRANSPLANTATION IN HEPATITIS DELTA VIRUS DISEASE
| Autor: | M. Doglia, R. Cortesini, Giorgio Verme, D. Alfani, S Macagno, E. Chiaberge, L. R. Fassati, G. Marinucci, C. Di Giacomo, D. Galmarini, F Milazzo, M. Rizzetto, Francesco Negro |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Viral Hepatitis Vaccines HBsAg Cirrhosis viruses medicine.medical_treatment Liver transplantation medicine.disease_cause Recurrence medicine Humans Hepatitis B Vaccines Hepatitis B Antibodies Hepatitis B virus Hepatitis Hepatitis B Surface Antigens business.industry virus diseases General Medicine Middle Aged biochemical phenomena metabolism and nutrition Hepatitis B medicine.disease Virology Hepatitis D digestive system diseases Liver Transplantation Transplantation Evaluation Studies as Topic Female Serum Globulins Viral disease business Viral hepatitis |
| Zdroj: | The Lancet. 330:469-471 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(87)91789-2 |
| Popis: | Seven patients with hepatitis delta virus (HDV) cirrhosis underwent liver transplantation. In every case the HDV infection was florid but accompanied by an inactive hepatitis B virus (HBV) infection. The patients were given anti-HB surface antigen (HBsAg) serum globulins and HBV vaccine. Two patients cleared the HBsAg and the HDV, and are alive and well 14 and 15 months, respectively, after transplantation. HDV infection recurred in the other five patients: hepatitis developed in three, another died, and the fifth was re-transplanted for causes unrelated to viral hepatitis (reinfection was shown by the presence of HD antigen in the graft). Liver transplantation is feasible in patients with HDV disease but involves a high risk of HDV reinfection that cannot be predicted by the virological pattern of the native HBV infection or prevented by conventional HBV prophylaxis. |
| Databáze: | OpenAIRE |
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