Pseudoexfoliation syndrome without glaucoma: White matter abnormalities detected by conventional MRI and diffusion tensor imaging
| Autor: | Vasileios G. Xydis, Maria I. Argyropoulou, George Kitsos, Eleni Bagli, Loukas G. Astrakas, Anastasia K. Zikou, Konstantinos Spiliopoulos |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Fluid-attenuated inversion recovery Exfoliation Syndrome Corpus Callosum White matter 03 medical and health sciences Nerve Fibers 0302 clinical medicine Fasciculus Fractional anisotropy medicine Humans Radiology Nuclear Medicine and imaging Inferior longitudinal fasciculus Brain Diseases biology business.industry Superior longitudinal fasciculus Glaucoma General Medicine Middle Aged biology.organism_classification Magnetic Resonance Imaging White Matter Hyperintensity Diffusion Tensor Imaging Early Diagnosis medicine.anatomical_structure nervous system 030221 ophthalmology & optometry Anisotropy Female business Nuclear medicine 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | European Journal of Radiology. 99:82-87 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2017.12.019 |
| Popis: | Purpose To assess macro- and microstructural brain changes in patients with pseudoexfoliation syndrome (PXS). Materials and methods Comprehensive ophthalmic examination and brain MRI were conducted on 20 patients with PXS without glaucoma (aged 62.75 ± 0.4 years) and 20 controls (aged 62 ± 0.6 years). White matter (WM) integrity was evaluated on FLAIR and single-shot multisection SE-EPI diffusion tensor imaging (DTI) sequences. The presence and the number of white matter hyperintensities (WMHIs) on FLAIR images was compared between all patients and control subjects. Microstructural WM changes on DTI was evaluated using Tract-based spatial statistics (TBSS). DTI metrics of the optic tracts were assessed by the region-of-interest (ROI) method. Results A significantly higher number of WMHIs was found in the patients with PXS than in the control subjects (P ≤ 0.002). On DTI the patients showed bilateral increase in the mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) values in the anterior thalamic radiation, the inferior fronto-occipital fasciculus, the superior longitudinal fasciculus, the inferior longitudinal fasciculus and the forceps minor. TBSS revealed no significant difference in fractional anisotropy (FA) values, but ROIs analysis of the optic tracts revealed decreased FA values in the patients. Conclusion MRI in patients with PXS detects abnormalities in the brain and the optic tracts at a subclinical stage. Early detection of microstructural changes could be useful to guide appropriate treatment to impede the disease process. |
| Databáze: | OpenAIRE |
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