Association of Serum Cholesterol Levels with Short-term Mortality in Patients with Acute Pulmonary Embolism
| Autor: | Gündüz Durmuş, Göktürk İpek, Zeki Yüksel Günaydın, Mehmet Karataş, Nizamettin Selçuk Yelgeç, Yiğit Çanga, Barış Güngör, Tolga Onuk, Hale Yilmaz, Osman Bolca |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty 030204 cardiovascular system & hematology Gastroenterology Disease-Free Survival 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Intensive care medicine Survival rate Triglycerides Serum cholesterol Aged Retrospective Studies Aged 80 and over Triglyceride business.industry Mortality rate Cholesterol HDL Retrospective cohort study Cholesterol LDL Middle Aged medicine.disease Pathophysiology Pulmonary embolism Hospitalization Survival Rate chemistry Acute Disease Population study Female lipids (amino acids peptides and proteins) Pulmonary Embolism Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart, Lung and Circulation. 25:365-370 |
| ISSN: | 1443-9506 |
| DOI: | 10.1016/j.hlc.2015.09.005 |
| Popis: | Serum cholesterols play an important role in pathophysiology and prognosis of acute thrombotic diseases. The aim of the present study was to investigate the prognostic value of serum lipid parameters in acute pulmonary embolism (APE).From January 2008 to January 2014 a total of 275 patients who were hospitalised with a diagnosis of APE were retrospectively screened. Clinical data, laboratory parameters, serum cholesterol levels were recorded and pulmonary embolism severity index (PESI) scores were calculated. Mortality rate at 30 days was investigated as the clinical outcome.In our study population, 24 patients (8.7%) died within 30 days. Serum total cholesterol, LDL-C, HDL-C and triglyceride levels were significantly lower in deceased patients when compared to the survived patients (3.1 ± 0.6 vs. 4.7 ± 1.2 mmol/L, p0.01; 1.8 ± 0.9 vs. 2.9 ± 0.9 mmol/L, p0.01; 0.9 ± 0.3 vs. 1.2 ± 0.3 mmol/L, p0.01; 1.4 ± 0.7 vs. 1.7 ± 0.6 mmol/L, p = 0.04, respectively). In multivariate regression analysis; PESI scores (OR: 1.06 95% CI: 1.01-1.11, p0.01), right ventricular diameter (OR: 11.31 95% CI: 3.25-52.64, p0.01), total cholesterol (OR: 1.09 95% CI: 1.02-1.17, p0.01), LDL-C (OR: 1.06 95% CI: 1.01-1.12, p = 0.02), HDL-C (OR: 1.21 95% CI: 1.04-1.41, p0.01) and triglyceride (OR: 1.03 95% CI: 1.01-1.05, p0.01) levels were independently correlated with mortality.Serum total cholesterol, LDL-C, HDL-C and triglyceride levels, obtained within the first 24hours of hospital admission, may have prognostic value in patients with APE. |
| Databáze: | OpenAIRE |
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