The history of the capillary wall: doctors, discoveries, and debates
| Autor: | William C. Aird, Charlotte Hwa |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
business.industry
Physiology Cardiology Models Cardiovascular History 19th Century Take over Anatomy History 20th Century History 18th Century History 21st Century humanities Epistemology Structure and function Capillaries Dilemma Cardiovascular Physiological Phenomena History 17th Century Physiology (medical) Physicians Medicine Animals Humans Cardiology and Cardiovascular Medicine business |
| Zdroj: | American journal of physiology. Heart and circulatory physiology. 293(5) |
| ISSN: | 0363-6135 |
| Popis: | In 1628, William Harvey provided definitive evidence that blood circulates. The notion that blood travels around the body in a circle raised the important question of how nutrients pass between blood and underlying tissue. Perhaps, Harvey posited, arterial blood pours into the flesh as into a sponge, only then to find its way into the veins. Far from solving this problem, Marcello Malpighi's discovery of the capillaries in 1661 only added to the dilemma: surely, some argued, these entities are little more than channels drilled into tissues around them. As we discuss in this review, it would take over 200 years to arrive at a consensus on the basic structure and function of the capillary wall. A consideration of the history of this period provides interesting insights into not only the central importance of the capillary as a focus of investigation, but also the enormous challenges associated with studying these elusive structures. |
| Databáze: | OpenAIRE |
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