| Autor: |
Hong-Kun Liu, Furong Lin, Shang-Bo Yu, Yan Wu, Shuai Lu, Yue-Yang Liu, Qiao-Yan Qi, Jin Cao, Wei Zhou, Xiaopeng Li, Hui Wang, Dan-Wei Zhang, Zhan-Ting Li, Da Ma |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of medicinal chemistry. 65(24) |
| ISSN: |
1520-4804 |
| Popis: |
Broad-spectrum agents for the reversal of residual curarization induced by neuromuscular blocking agents are of great significance. Here, we report a highly water-soluble cucurbit[8]uril (CB[8]) derivative as a broad-spectrum neuromuscular block reversal agent induced by both benzylisquinolinium and aminosteroid neuromuscular block agents by the supramolecular sequestration strategy. The UV/Vis competition titration assays suggest the high binding affinity of the CB[8] derivative toward both benzylisquinolinium-type cisatracurium besylate and aminosteroid-type rocuronium, vecuronium, and pancuronium, at the level of 10 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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