Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates

Autor: Liza Romero-Murillo, Manuel A. Patarroyo, Luisa F. Tobón, Diego Garzón-Ospina
Rok vydání: 2010
Předmět:
Unclassified drug
Plasmodium vivax
Protozoan Proteins
Vivax
Polymerase Chain Reaction
Malaria vaccines
Genotype
Membrane proteins
Haplotype
Merozoite surface protein
Priority journal
Genetics
biology
Geography
Malaria vaccine
Polymerase chain reaction
Infectious Diseases
Merozoite surface protein 7a
Genetic conservation
Host-parasite interactions
Merozoite surface protein 7k
Vaccine candidate
Microbiology (medical)
Protozoan proteins
Molecular Sequence Data
Merozoite surface protein 10
Antigens
Protozoan
Colombia
complex mixtures
Microbiology
Article
Host-Parasite Interactions
Molecular sequence data
Genetic variation
parasitic diseases
Malaria Vaccines
medicine
Malaria
Vivax
Humans
Genetic variability
Antigens
Polymorphism
Molecular Biology
Ecology
Evolution
Behavior and Systematics
Genetic diversity
Genetic polymorphism
Polymorphism
Genetic
protozoan
Genetic Variation
Membrane Proteins
medicine.disease
biology.organism_classification
Nonhuman
Virology
Malaria
Membrane protein
genetic
Controlled study
Nucleotide sequence
Zdroj: Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
ISSN: 1567-7257
Popis: The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V.
Databáze: OpenAIRE
Externí odkaz: