Retained particle surface area dose drives inflammation in rat lungs following acute, subacute, and subchronic inhalation of nanomaterials

Autor: Ulla Vogel, Sarah Valentino, Laurent Gaté, Carole Seidel, Otmar Schmid, Frédéric Cosnier, Jérôme Devoy, Sébastien Bau
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Health
Toxicology and Mutagenesis
02 engineering and technology
010501 environmental sciences
Pharmacology
Toxicology
01 natural sciences
RA1190-1270
Lung
Inhalation exposure
Multiwall carbon nanotube
Inhalation Exposure
medicine.diagnostic_test
Inhalation
Chemistry
General Medicine
HD7260-7780.8
021001 nanoscience & nanotechnology
medicine.anatomical_structure
medicine.symptom
0210 nano-technology
Neutrophil influx
Bronchoalveolar Lavage Fluid
SBET
Retained surface area
Inflammation
Carbon black
MPPD
Administration
Inhalation
medicine
Potency
Dosimetry
Animals
Particle Size
Aerosol
0105 earth and related environmental sciences
Dose-Response Relationship
Drug
Nanotubes
Carbon
Carbon Black
Mppd
Multiwall Carbon Nanotube
Neutrophil Influx
Rat
Retained Surface Area
Sbet
Titanium Dioxide
Research
Nanostructures
Rats
Bronchoalveolar lavage
Toxicology. Poisons
Particle
Titanium dioxide
Industrial hygiene. Industrial welfare
Zdroj: Particle and Fibre Toxicology, Vol 18, Iss 1, Pp 1-21 (2021)
Particle and Fibre Toxicology
Cosnier, F, Seidel, C, Valentino, S, Schmid, O, Bau, S, Vogel, U, Devoy, J & Gaté, L 2021, ' Retained particle surface area dose drives inflammation in rat lungs following acute, subacute, and subchronic inhalation of nanomaterials ', Particle and Fibre Toxicology, vol. 18, no. 1, 29 . https://doi.org/10.1186/s12989-021-00419-w
Part. Fibre Toxicol. 18:29 (2021)
ISSN: 1743-8977
Popis: Background An important aspect of nanomaterial (NM) risk assessment is establishing relationships between physicochemical properties and key events governing the toxicological pathway leading to adverse outcomes. The difficulty of NM grouping can be simplified if the most toxicologically relevant dose metric is used to assess the toxicological dose-response. Here, we thoroughly investigated the relationship between acute and chronic inflammation (based on polymorphonuclear neutrophil influx (% PMN) in lung bronchoalveolar lavage) and the retained surface area in the lung. Inhalation studies were performed in rats with three classes of NMs: titanium dioxides (TiO2) and carbon blacks (CB) as poorly soluble particles of low toxicity (PSLT), and multiwall carbon nanotubes (MWCNTs). We compared our results to published data from nearly 30 rigorously selected articles. Results This analysis combined data specially generated for this work on three benchmark materials - TiO2 P25, the CB Printex-90 and the MWCNT MWNT-7 - following subacute (4-week) inhalation with published data relating to acute (1-week) to subchronic (13-week) inhalation exposure to the classes of NMs considered. Short and long post-exposure recovery times (immediately after exposure up to more than 6 months) allowed us to examine both acute and chronic inflammation. A dose-response relationship across short-term and long-term studies was revealed linking pulmonary retained surface area dose (measured or estimated) and % PMN. This relationship takes the form of sigmoid curves, and is independent of the post-exposure time. Curve fitting equations depended on the class of NM considered, and sometimes on the duration of exposure. Based on retained surface area, long and thick MWCNTs (few hundred nm long with an aspect ratio greater than 25) had a higher inflammatory potency with 5 cm2/g lung sufficient to trigger an inflammatory response (at 6% PMN), whereas retained surfaces greater than 150 cm2/g lung were required for PSLT. Conclusions Retained surface area is a useful metric for hazard grouping purposes. This metric would apply to both micrometric and nanometric materials, and could obviate the need for direct measurement in the lung. Indeed, it could alternatively be estimated from dosimetry models using the aerosol parameters (rigorously determined following a well-defined aerosol characterization strategy).
Databáze: OpenAIRE
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