Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk
Autor: | Chantal Guillemette, Stephen K. Van Den Eeden, Michael B. Cook, Giske Ursin, Elio Riboli, Louise A. Brinton, Elisabete Weiderpass, Dominick Parisi, Howard D. Sesso, Patrick Caron, Roni T. Falk, Claudine Isaacs, Véronique Turcotte, Karin B. Michels, Laurence N. Kolonel, Laurel A. Habel, Shannon N. Wood, Timothy J. Key |
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Rok vydání: | 2015 |
Předmět: |
Male
PREMENOPAUSAL Cancer Research medicine.medical_specialty International Cooperation Physiology Breast Neoplasms Male EPIC COHORT Cohort Studies REPLACEMENT THERAPY Risk Factors Internal medicine BASE-LINE CHARACTERISTICS Odds Ratio Humans Medicine Oncology & Carcinogenesis Gonadal Steroid Hormones Prospective cohort study ESTROGEN METABOLISM Aged Science & Technology Estradiol business.industry Case-control study MEN ORIGINAL REPORTS Odds ratio Middle Aged medicine.disease KLINEFELTER-SYNDROME Hormones BODY-MASS INDEX Endocrinology POSTMENOPAUSAL WOMEN Oncology Case-Control Studies Male breast cancer Multivariate Analysis Cohort Androgens COLLABORATIVE REANALYSIS business Life Sciences & Biomedicine 1112 Oncology And Carcinogenesis Body mass index Cohort study Hormone |
Zdroj: | Journal of Clinical Oncology. 33:2041-2050 |
ISSN: | 1527-7755 0732-183X |
Popis: | Purpose Although previous studies have implicated a variety of hormone-related risk factors in the etiology of male breast cancers, no previous studies have examined the effects of endogenous hormones. Patients and Methods Within the Male Breast Cancer Pooling Project, an international consortium comprising 21 case-control and cohort investigations, a subset of seven prospective cohort studies were able to contribute prediagnostic serum or plasma samples for hormone quantitation. Using a nested case-control design, multivariable unconditional logistic regression analyses estimated odds ratios and 95% CIs for associations between male breast cancer risk and 11 individual estrogens and androgens, as well as selected ratios of these analytes. Results Data from 101 cases and 217 matched controls were analyzed. After adjustment for age and date of blood draw, race, and body mass index, androgens were found to be largely unrelated to risk, but circulating estradiol levels showed a significant association. Men in the highest quartile had an odds ratio of 2.47 (95% CI, 1.10 to 5.58) compared with those in the lowest quartile (trend P = .06). Assessment of estradiol as a ratio to various individual androgens or sum of androgens showed no further enhancement of risk. These relations were not significantly modified by either age or body mass index, although estradiol was slightly more strongly related to breast cancers occurring among younger (age < 67 years) than older men. Conclusion Our results support the notion of an important role for estradiol in the etiology of male breast cancers, similar to female breast cancers. |
Databáze: | OpenAIRE |
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