A clinical study of neurological soft signs in patients with schizophrenia
| Autor: | Subrata Naskar, Aparajeeta Baruah, Kamal Nath, Mithun Dutta |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pediatrics
medicine.medical_specialty Neurological soft signs lcsh:RC321-571 Clinical study 03 medical and health sciences 0302 clinical medicine Medicine In patient 030212 general & internal medicine Psychiatry lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry business.industry General Neuroscience Confounding Tertiary care hospital medicine.disease 030227 psychiatry endophenotype schizophrenia Brain region neurological soft signs Schizophrenia Endophenotype Original Article Demographics Neurology (clinical) business |
| Zdroj: | Journal of Neurosciences in Rural Practice Journal of Neurosciences in Rural Practice, Vol 07, Iss 03, Pp 393-399 (2016) |
| ISSN: | 0976-3155 0976-3147 |
| Popis: | Background and Aim: Neurological soft signs (NSSs) are “objectively measured, nonlocalizing abnormalities, not related to impairment of a specific brain region, reflecting improper cortical-subcortical and intercortical connections.” The possibility of NSS as an endophenotype in schizophrenia has been studied across the globe. We aimed at finding the prevalence of NSS among patients with schizophrenia as well as the associations of NSS between various sociodemographic and illness variables. Subjects and Methods: One hundred patients between the age group of 16 and 60 years were serially selected from the inpatient department of a tertiary care hospital who have been diagnosed as a case of schizophrenia according to the International Classification of Diseases version 10 during 1 year period. A semi-structured pro forma was used to collect various demographic as well as illness data, and subjects were clinically evaluated for NSS using neurological evaluation scale. Results: The prevalence of NSSs was found to be 67%, significant association was found between NSS and age, occupation, and duration of illness. A statistically significant correlation was found between NSS and age, NSS and duration of illness. Conclusion: The validity of NSS as an endophenotype lies in the fact that it should be independent of all sociodemographic and illness variables. However, our study evaluated some statistically significant findings between them. Hence, further researches are required with properly adjusted controls to find if the associations obtained between NSS and different variables here are true or whether there are some confounding factors included. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|