Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest

Autor: Ulf-Håkan Stenman, Johanna Wennervirta, Anne Vakkuri, Anna Lempiäinen, Hannu Koistinen, Kristina Hotakainen, Juhani A Stewart, Riitta Koistinen, Ulla-Stina Salminen
Přispěvatelé: Kardiologian yksikkö, Helsinki University Hospital Area, University of Helsinki, Medicum, HUSLAB, Department of Clinical Chemistry and Hematology, Päivi Hotakainen / Principal Investigator, HUS Heart and Lung Center, III kirurgian klinikka, Department of Surgery, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Clinicum, Department of Diagnostics and Therapeutics, HUS Abdominal Center
Rok vydání: 2020
Předmět:
Male
Clinical Biochemistry
hCG beta
030204 cardiovascular system & hematology
Gastroenterology
chemistry.chemical_compound
SPINK1
0302 clinical medicine
Chorionic Gonadotropin
beta Subunit
Human
Trypsin
Prospective Studies
Aorta
Immunoassay
Cardiopulmonary Bypass
General Medicine
Middle Aged
3. Good health
Aortic Aneurysm
Perfusion
Circulatory Arrest
Deep Hypothermia Induced
Trypsin Inhibitor
Kazal Pancreatic
030220 oncology & carcinogenesis
Cerebrovascular Circulation
Circulatory system
Trypsinogen
Female
medicine.drug
Adult
medicine.medical_specialty
Trypsin inhibitor
Critical Illness
aortic surgery
DIAGNOSIS
Hypothermic circulatory arrest
VALIDATION
03 medical and health sciences
medicine.artery
Internal medicine
Ascending aorta
medicine
Humans
Cerebral perfusion pressure
Aged
business.industry
Cancer
3126 Surgery
anesthesiology
intensive care
radiology
medicine.disease
Aortic Dissection
chemistry
Pancreatitis
business
AMYLASE
Biomarkers
Zdroj: Scandinavian journal of clinical and laboratory investigation. 80(8)
ISSN: 1502-7686
Popis: The concentrations of several diagnostic markers have been found to increase dramatically in critically ill patients with a severe disturbance of normal physiological homeostasis, without indication of the diseases they are normally associated with. To prevent false diagnoses and inappropriate treatments of critically ill patients, it is important that the markers aiding the selection of second-line treatments are evaluated in such patients and not only in the healthy population and patients with diseases the markers are associated with. The levels of trypsinogen isoenzymes, the trypsin inhibitor serine peptidase inhibitor Kazal type 1 (SPINK1), hCG and hCG beta, which are used as pancreatitis and cancer markers, were analyzed by immunoassays from serum samples of 17 adult patients who have undergone surgery of the ascending aorta during hypothermic circulatory arrest (HCA) with optional selective cerebral perfusion. Highly elevated levels of trypsinogen-1, -2 and -3, SPINK1 and hCG beta were observed in patients after HCA. This was accompanied by increased concentrations of S100 beta and NSE. In conclusion, this study highlights the importance of critically evaluating the markers used for aiding selection of second line of treatments in critically ill patients.
Databáze: OpenAIRE
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