Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest
Autor: | Ulf-Håkan Stenman, Johanna Wennervirta, Anne Vakkuri, Anna Lempiäinen, Hannu Koistinen, Kristina Hotakainen, Juhani A Stewart, Riitta Koistinen, Ulla-Stina Salminen |
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Přispěvatelé: | Kardiologian yksikkö, Helsinki University Hospital Area, University of Helsinki, Medicum, HUSLAB, Department of Clinical Chemistry and Hematology, Päivi Hotakainen / Principal Investigator, HUS Heart and Lung Center, III kirurgian klinikka, Department of Surgery, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Clinicum, Department of Diagnostics and Therapeutics, HUS Abdominal Center |
Rok vydání: | 2020 |
Předmět: |
Male
Clinical Biochemistry hCG beta 030204 cardiovascular system & hematology Gastroenterology chemistry.chemical_compound SPINK1 0302 clinical medicine Chorionic Gonadotropin beta Subunit Human Trypsin Prospective Studies Aorta Immunoassay Cardiopulmonary Bypass General Medicine Middle Aged 3. Good health Aortic Aneurysm Perfusion Circulatory Arrest Deep Hypothermia Induced Trypsin Inhibitor Kazal Pancreatic 030220 oncology & carcinogenesis Cerebrovascular Circulation Circulatory system Trypsinogen Female medicine.drug Adult medicine.medical_specialty Trypsin inhibitor Critical Illness aortic surgery DIAGNOSIS Hypothermic circulatory arrest VALIDATION 03 medical and health sciences medicine.artery Internal medicine Ascending aorta medicine Humans Cerebral perfusion pressure Aged business.industry Cancer 3126 Surgery anesthesiology intensive care radiology medicine.disease Aortic Dissection chemistry Pancreatitis business AMYLASE Biomarkers |
Zdroj: | Scandinavian journal of clinical and laboratory investigation. 80(8) |
ISSN: | 1502-7686 |
Popis: | The concentrations of several diagnostic markers have been found to increase dramatically in critically ill patients with a severe disturbance of normal physiological homeostasis, without indication of the diseases they are normally associated with. To prevent false diagnoses and inappropriate treatments of critically ill patients, it is important that the markers aiding the selection of second-line treatments are evaluated in such patients and not only in the healthy population and patients with diseases the markers are associated with. The levels of trypsinogen isoenzymes, the trypsin inhibitor serine peptidase inhibitor Kazal type 1 (SPINK1), hCG and hCG beta, which are used as pancreatitis and cancer markers, were analyzed by immunoassays from serum samples of 17 adult patients who have undergone surgery of the ascending aorta during hypothermic circulatory arrest (HCA) with optional selective cerebral perfusion. Highly elevated levels of trypsinogen-1, -2 and -3, SPINK1 and hCG beta were observed in patients after HCA. This was accompanied by increased concentrations of S100 beta and NSE. In conclusion, this study highlights the importance of critically evaluating the markers used for aiding selection of second line of treatments in critically ill patients. |
Databáze: | OpenAIRE |
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