Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues
| Autor: | Ernesto Menta, Ambrogio Oliva, Giuseppe Zagotto, Manlio Palumbo, Fulvio Guano, Giovanni Capranico |
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| Rok vydání: | 1998 |
| Předmět: |
Stereochemistry
Clinical Biochemistry Pharmaceutical Science Hydrazone Antineoplastic Agents Cleavage (embryo) Biochemistry Chemical synthesis chemistry.chemical_compound Drug Discovery Tumor Cells Cultured medicine Humans Cytotoxicity Molecular Biology Amsacrine Anthracenes chemistry.chemical_classification biology Chemistry Topoisomerase Organic Chemistry DNA Topoisomerases Type II biology.protein Molecular Medicine Bisantrene DNA DNA Damage medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 8:121-126 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(97)10207-4 |
| Popis: | New bisantrene analogues were synthesized, bearing one or two 4,5-dihydro-1H-imidazol-2-yl hydrazone side chains at positions 1,4 or 9 of the anthracene ring system. A 10-azabioisostere was also prepared. The position of substituents in structurally isomeric drugs modulates topoisomerase II poisoning and specificity, along with cytotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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