Thrombin generation in Cushing’s Syndrome: do the conventional clotting indices tell the whole truth?
| Autor: | Sara Maggiolo, S. Koutroumpi, Maria Bon, Sabrina Gavasso, Carla Scaroni, Franco Mantero, Anna Chiara Frigo, Mattia Barbot, Paolo Simioni, Nora Albiger, Luca Spiezia |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Diabetes Complications Endocrinology Thrombin Internal medicine medicine Humans Obesity Blood Coagulation Cushing Syndrome Aged Dyslipidemias Blood coagulation test Aged 80 and over Metabolic Syndrome Prothrombin time medicine.diagnostic_test business.industry Antithrombin Middle Aged medicine.disease Venous thrombosis Hypertension Female Blood Coagulation Tests Metabolic syndrome business Protein C Partial thromboplastin time medicine.drug |
| Zdroj: | Pituitary. 17:68-75 |
| ISSN: | 1573-7403 1386-341X |
| DOI: | 10.1007/s11102-013-0467-3 |
| Popis: | Cushing’s Syndrome (CS) is associated with an increased mortality, where hypercoagulability seems to have a crucial role in both arterial and venous thrombosis. Parameters of in vitro thrombin generation (TG) such as lag time, peak thrombin and endogenous thrombin potential (ETP), that describe the time until thrombin burst, the peak amount of TG and the total amount of thrombin generated, respectively as well as classical clotting markers were evaluated in 33 CS patients compared to both a group of 28 patients matched for the features of Metabolic Syndrome (MetS) and 31 healthy individuals. CS and MetS patients had shorter lag time (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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