Indirektna procjena referentnih intervala za parametre štitne žlijezde upotrebom advia centaur XP analizatora
| Autor: | Bosa Mirjanić-Azarić, Neda Milinković, Natasa Bogavac-Stanojević, Sanja Avram, Tanja Stojaković-Jelisavac, Darja Stojanović |
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| Rok vydání: | 2022 |
| Předmět: |
indirektne metode
Original Paper indirect methods business.industry Biochemistry (medical) Clinical Biochemistry Thyroid Analyser parametri štitne žlezde Reference intervals thyroid parameters medicine.anatomical_structure reference intervals medicine ADVIA Centaur referentni intervali Nuclear medicine business hormones hormone substitutes and hormone antagonists Mathematics |
| Zdroj: | Journal of Medical Biochemistry J Med Biochem |
| Popis: | Background: The aim of this study was to determine the reference intervals (RIs) for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and FT3/FT4 ratio using indirect methods. Methods: We analyzed 1256 results TSH, FT4 and FT3 collected from a laboratory information system between 2017 and 2021. All measurements were performed on a Siemens ADVIA Centaur XP analyzer using the chemiluminescent immunoassay. We calculated the values of the 2.5th and 97.5th percentiles as recommended by the IFCC (CLSI C28-A3). Results: The RIs derived for TSH, FT4, FT3 and FT3/FT4 ratio were 0.34–4.10 mIU/L, 11.3–20.6 pmol/L, 3.5–6.32 pmol/L and 0.21–0.47, respectively. We found a significant difference between calculated RIs for the TSH and FT4 and those recommended by the manufacturer. Also, FT3 values were significantly higher in the group younger than 30 years relative to the fourth decade (5.26 vs. 5.02, p=0.005), the fifth decade (5.26 vs. 4.94, p=0.001), the sixth decade (5.26 vs. 4.87, p |
| Databáze: | OpenAIRE |
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