Effect of rosuvastatin on dyslipidemia and other parameters associated with metabolic syndrome in Saudi patients
| Autor: | Misbahuddin M Rafeeq, Hussam As Murad, M A Gari, Z.J. Gazzaz, Hamed S. Habib |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Very low-density lipoprotein medicine.medical_specialty Statin medicine.drug_class Saudi Arabia Blood lipids 030226 pharmacology & pharmacy Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Internal medicine Medicine Humans Rosuvastatin Prospective Studies Rosuvastatin Calcium National Cholesterol Education Program Triglycerides Dyslipidemias Metabolic Syndrome Cholesterol business.industry Cholesterol HDL General Medicine Cholesterol LDL Middle Aged medicine.disease Endocrinology chemistry 030220 oncology & carcinogenesis lipids (amino acids peptides and proteins) Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Morbidity Goal insulin resistance lipid obesity statin business Dyslipidemia medicine.drug |
| Zdroj: | Nigerian Journal of Clinical Practice; Vol 20, No 4 (2017); 445-453 |
| ISSN: | 1119-3077 |
| Popis: | Context: Metabolic syndrome (MS) is a constellation of metabolic irregularities consisting of dyslipidemia, hypertension, hyperglycemia, chronic inflammatory, and hypercoagulable state predisposing to diabetes and cardiovascular events. Statins are first-line drugs to treat the associated atherogenic dyslipidemia.Aim: Effect of rosuvastatin on MS in Saudi patients was studied. Settings andDesign: Prospective, open label, randomized clinical study. Materials and Methods: Patients of either sex ≥18 years (n = 153) having MS as per modified National Cholesterol Education Program Adult Treatment Panel III criteria were prescribed rosuvastatin 10 mg OD for 24 weeks. Serum lipids, biochemical, clinical, and anthropometric parameters were studied before and after treatment.Statistical Analysis Used: Statistical Package for Social Sciences version17 was used. Descriptive analysis was used for all variables and documented as mean ± SD. Normality checked by Shapiro–Wilk test, Kurtosis and Skewness Z-score, and visualization of histograms. Lipid levels and other parameters before and after treatment were evaluated by paired t-test for parametric data and Wilcoxon signed rank test for nonparametric data. Pre- and post-test values were correlated by Pearson’s correlation coefficient. Multiple regression analysis was performed to see effect of other variables.Results: Highly significant reduction was observed in low density lipoprotein cholesterol, total cholesterol, triglycerides; very low density lipoprotein cholesterol, non-high density lipoprotein cholesterol and atherosclerotic index with an elevation in high density lipoprotein cholesterol. A total of 86% patients reached low density lipoprotein cholesterol goal of ≤ 100 mg/dL. Beneficial response was observed on other associated parameters. There was strong correlation between pre- and post values. No significant effect was observed for any of the variables on cholesterol reduction. No serious/severe adverse effect was observed.Conclusion: Rosuvastatin markedly improved atherogenic dyslipidemia of MS.Keywords: Goal, insulin resistance, lipid, obesity, statin |
| Databáze: | OpenAIRE |
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